+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of hepatic glycogen synthesis during fetal development: roles of hydrocortisone, insulin, and insulin receptors

, : Regulation of hepatic glycogen synthesis during fetal development: roles of hydrocortisone, insulin, and insulin receptors. Proceedings of the National Academy of Sciences of the United States of America 70(12): 3454-3457

In fetal rat liver in utero, an increase in glycogen and the glycogen synthetic enzyme glycogen synthetase (EC occurs between gestational days 17 and 19. We used an organ culture system for finding the stimulus for increased enzyme activity and defining the relationship of this increase to glycogen synthesis. In fetal-liver explants from an earlier period (gestational day 16), hydrocortisone causes an elevation in total glycogen synthetase activity. This effect, which can be blocked by actinomycin D, is strikingly similar in time course and magnitude to the normal increase in utero. However, in order for glycogen synthesis to proceed after hydrocortisone increases glycogen synthetase levels, insulin is required. Unlike hydrocortisone, insulin does not increase total glycogen synthetase; it appears to act by converting the b or phospho form of synthetase to the a or dephospho form. Insulin alone does not stimulate glycogen synthesis in explants from 16-day fetal liver, although no defect in insulin binding was demonstrable. These findings support the hypothesis that the increase in liver-glycogen synthesis during the last trimester requires glucocorticoids for the developmental induction of glycogen synthetase and insulin for activation of the enzyme.

(PDF same-day service: $19.90)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006288402

PMID: 4357871

DOI: 10.1073/pnas.70.12.3454

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Littlejohns, I. R., 2003: Anonymity of referees. Australian Veterinary Journal 81(6): 363, June

Hwang, U.W.; Shin, K.S.; Ryu, J.S.; Min, D.Y.; Ahn, M.H., 2002: Phylogenetic relationships between the six superoxide dismutase proteins (FeSOD) of Trichomonas vaginalis and FeSOD6 genetic diversity. The parasitic protozoan Trichomonas vaginalis is known to contain several types of Fe-containing superoxide dismutase proteins (FeSOD). Using three different methods of phylogenetic analysis, maximum parsimony (MP), neighbor joining (NJ), and maxi...

Campbell, Gilbert S., 1954: Effect of pH changes on vagal inhibition of the heart. Dissertation Absts 14(8): 1244

Breen,M., 2008: Canine cytogenetics - from band to basepair. Humans and dogs have coexisted for thousands of years, during which time we have developed a unique bond, centered on companionship. Along the way, we have developed purebred dog breeds in a manner that has resulted unfortunately in many of them b...

Anand, B. S.; Torres, E.; Operkun, A.; Graham, D. Y., 1994: Comparative assessment of phenolphthalein and phenolphthalein glucuronide: Is phenolphthalein glucuronide a better laxative?. Background: Phenolphthalein is widely used as a safe and effective laxative. After oral administration, phenolphthalein is absorbed in the small bowel and is conjugated in the liver to phenolphthalein glucuronide which passes into the colon where...

Nomura, Naofumi; Kikuzawa, Kihachiro, 2003: Productive phenology of tropical montane forests: Fertilization experiments along a moisture gradient. Phenological responses of leaves and roots were studied in the tropical montane forests of Mount Kinabalu, Borneo. Soil nutrient supply, in addition to the supply of light and water, is a potential abiotic factor influencing plant phenology in the...

Elliott, A.M.; Halwiindi, B.; Hayes, R.J.; Luo, N.; Tembo, G.; Machiels, L.; Bem, C.; Steenbergen, G.; Pobee, J.O.; Nunn, P.P., 1993: The impact of human immunodeficiency virus on presentation and diagnosis of tuberculosis in a cohort study in Zambia. Two hundred and forty-nine patients with tuberculosis were recruited to a cohort study to investigate the interaction between tuberculosis and HIV in Lusaka, Zambia; findings at presentation are presented here. One hundred and eighty-two (73%; 95%...

Dondale, C. D., 1963: Florida spiders in the rufus group in the genus Philodromus (Araneae : Thomisidae). Psyche, 70: 34-43

Klyuchevskiy, A. V., 2010: Changes in earthquake energy class as a factor affecting parameters of recurrence relation in the Baikal region. The numerical modeling of actually observed events contained in the Baikal earthquake catalog allowed the production of man-nade catalogs. These catalogs reflect real situations that can give rise to heterogeneities in earthquake catalogs acquired...

R. N. Tomezzoli, 2001: Further palaeomagnetic results from the Sierras Australes fold and thrust belt, Argentina. Geophysical Journal International 147(2): 356-366