EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
EurekaMag PDF Full Text Supply ServicePDF Full Text Supply Service
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn
Follow on LinkedInFollow on Tumblr

+ Translate

Regulation of hepatocyte cyclic amp and pyruvate kinase by site specific analogs of adenosine


, : Regulation of hepatocyte cyclic amp and pyruvate kinase by site specific analogs of adenosine. Molecular & Cellular Endocrinology 26(3): 269-280

The effects of site-specific analogs of adenosine on cAMP content and pyruvate kinase activity of isolated rat hepatocytes were studied. N6-(Phenylisopropyl)adenosine (PIA), a metabolically stable analog of adenosine which acts specifically at 'R' sites, increased cAMP content and decreased pyruvate kinase activity to about the same extent as did epinephrine. By contrast, adenosine itself was without effect. Consistent with 'R'-site mediated effects, the effects of PIA were blocked by 3-isobutyl-1-methylxanthine. 2',5'-Dideoxyadenosine, which acts specifically at 'P' sites to inhibit adenylate cyclase, counteracted the effects of epinephrine on pyruvate kinase, but paradoxically not the effects of PIA. The adenylate cyclase in membranes from these parenchymal cells was determined and exhibited comparable sensitivity to 'R' site-specific analogs and other activators as did the enzyme prepared from whole liver. The effects on liver metabolism of 'R' site-specific analogs of adenosine apparently are initiated by an adenosine-receptor coupled activation of adenylate cyclase and these effects are characteristics of the parenchymal cells.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006288435

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Marcus R., 1987: Normal and abnormal bone remodeling in man. Creger, W P (Ed ) Annual Review Of Medicine: Selected Topics in The Clinical Sciences, Vol 38 X+533p Annual Reviews Inc : Palo Alto, California, Usa Illus 129-142

Chen, Xiao Ming; Hosono, Takayoshi; Mizuno, Aya; Yoda, Tamae; Yoshida, Kyoko; Aoyagi, Yukitoshi; Kanosue, Kazuyuki, 1998: New apparatus for studying behavioral thermoregulation in rats. The operant system described here contains a box that can be convectively heated or cooled. A rat moves freely in the box. Its location is monitored photoelectrically while its deep body temperature is monitored by a telemetry system. In heat-esca...

Zhang HeXiao; Wang CaiLan; Cui XiangDong; Wang Gang; Su ShiMin; Zhang YuZhong; Gan MengHou, 1997: Study on detecting antibodies against porcine reproductive and respiratory syndrome virus by an ELISA. An ELISA was developed for the detection of antibodies to porcine reproductive and respiratory syndrome virus. The coating concentration of antibody was 1.7 mg/litre, and the optimal dilution of serum was 1:100. The work concentration of peroxidas...

Esad Vucic; Stephen D. Dickson; Claudia Calcagno; James H.F. Rudd; Erin Moshier; Katsumi Hayashi; Jessica S. Mounessa; Michelle Roytman; Matthew J. Moon; James Lin; Sotirios Tsimikas; Edward A. Fisher; Klaas Nicolay; Valentin Fuster; Zahi A. Fayad, 2011: Pioglitazone Modulates Vascular Inflammation in Atherosclerotic Rabbits Noninvasive Assessment With FDG-PET-CT and Dynamic Contrast-Enhanced MR Imaging. We sought to determine the antiatherosclerotic properties of pioglitazone using multimethod noninvasive imaging techniques.Inflammation is an essential component of vulnerable or high-risk atheromas. Pioglitazone, a peroxisome proliferator-activat...

De La Fuente, Miguel Angel; Tovar, Victoria; Villamor, Neus; Zapater, Nuria; Pizcueta, Pilar; Campo, Elias; Bosch, Jaime; Engel, Pablo, 2001: Molecular characterization and expression of a novel human leukocyte cell-surface marker homologous to mouse Ly-9. Ly-9 is a mouse cell-surface glycoprotein that is selectively expressed on thymocytes and on mature T and B lymphocytes. Ly-9 belongs to the CD2 subset of the immunoglobulin superfamily, an emerging family of cell signaling receptors. Recently, a...

Anonymous, 1981: Reverse osmosis - PCI (Patterson Candy International) presents the MSR system which permits the degree of concentration to be increased. A description is given of the multi-stage recirculation system (MSR) of reverse osmosis (RI) developed by Paterson Candy International, and the advantages of RI over thermal methods of concentration are discussed. In factory trials, Gouda cheese w...

Swartz, C. M., 1998: Betaxolol hydrochloride for the treatment of anxiety disorders. Official Gazette of the United States Patent & Trademark Office Patents 1213(4): 3744, Aug 25

Liao WenYing; Palmer, R. G., 1997: Inheritance and linkage studies of 6-phosphogluconate dehydrogenase in soybean. The variant phosphogluconate dehydrogenase 1 null (Pgd1-n) has been found in Glycine max. Inheritance studies in the cross BSR101 (Pgd1-b/Pgd1-b) x PI567339 (Pgd1-n/Pgd1-n) showed that Pgd1-n was recessive to Pgd1-b at the Pgd1 locus. Linkage anal...

Seyama, H.; Kurita, H.; Noguchi, A.; Shiokawa, Y.; Saito, I., 2001: Resolution of intractable hiccups caused by cerebellar hemangioblastoma. Neurology 57(11): 2142, December 11

Thoma, Laura A.; Kiang, Patty H.; Murty, Ram; Sheth, Bhogi B., 1996: A clear plastic vial II Evaluation for packaging sterile, parenteral solutions. Pharmaceutical Research (New York) 13(9 SUPPL ): S226