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Regulation of herpesvirus macro molecular synthesis part 5 properties of alpha poly peptides made in herpes simplex virus type 1 and herpes simplex virus type 2 infected cells


, : Regulation of herpesvirus macro molecular synthesis part 5 properties of alpha poly peptides made in herpes simplex virus type 1 and herpes simplex virus type 2 infected cells. Virology 77(2): 733-749

Previous reports defined as .alpha. those viral polypeptides whose production in infected [human laryngeal carcinoma HEp-2] cells does not require prior protein synthesis. Two subsequent groups, .beta. and .gamma., depend on prior .alpha. and .beta. polypeptide synthesis, respectively. Comparison of the synthesis and properties of .alpha. polypeptides specified by herpes simplex viruses (HSV) 1 and 2 showed that the 3 earliest virus-specific infected cell polypeptides (ICP) made in HSV-2 infected cells migrated slightly more slowly in polyacrylamide gels than the HSV-1 .alpha. polypeptides, ICP 4.0 and 27. Cells treated with canavanine from the time of infection with HSV-2 produced all .alpha., a subset of .beta. and a small amount of 1 .gamma. polypeptide; the synthesis of these polypeptides continued for many hours, at rates related to the multiplicity of infection. The transition from .alpha. to this subset of .beta. polypeptide synthesis did not appear to be affected by the arginine analog, but transition to the other sets of .beta. and to .gamma. polypeptide synthesis was blocked. A similar discrimination between different subsets of .beta. proteins was seen in treated HSV-1 infected cells. All .alpha. and a number of .beta. polypeptides observed underwent translocation into the nucleus, post translational modification resulting in a reduced electrophoretic mobility and phosphorylation. The modification of HSV-1 and HSV-2 ICP 4 was in at least 2 steps from the translational product ICP 4a, labeled during a pulse, to slower-migrating forms ICP 4b and 4c. All 3 forms were phosphorylated, but only 4b and 4c were found in the nucleus. In untreated infected cells ICP 4 ultimately accumulated in form ICP 4c. ICP 4a made in the presence of canavanine was not processed efficiently into ICP 4c. In another instance the polypeptide made in the presence of canavanine was not translocated into nuclei.

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