EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
EurekaMag PDF Full Text Supply ServicePDF Full Text Supply Service
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn
Follow on LinkedInFollow on Tumblr

+ Translate

Regulation of herpesvirus macro molecular synthesis part 7 inhibition of internal methylation of messenger rna late in infection


, : Regulation of herpesvirus macro molecular synthesis part 7 inhibition of internal methylation of messenger rna late in infection. Virology 85(1): 146-156

Previous reports showed that herpes simplex virus RNA entering the cytoplasm has a terminal oligonucleotide structure consistent with 7mG(5')ppp-(5')XmpYmpNp and that, whereas the viral RNA made early in infection contained methylated mononucleotides, the RNA made late did not. This paper reports the following: viral and host [human epidermoid carcinoma HEp-2 cells] adenylated RNA made early in infection were methylated at both the 5' terminus and internally (6mAp); until the RNA made before the onset of synthesis of viral DNA, viral and host adenylated RNA entering the cytoplasm late in infection during the synthesis of .gamma. (structural) polypeptides were methylated at the 5' terminus but not internally; the cessation of methylation of internal nucleotides was not due to rapid turnover of the enzyme(s) responsible for this function; addition of canavanine at any time after infection and until shortly after onset of .beta.-polypeptide synthesis precluded this cessation of internal methylation of host and viral RNA; inhibition of viral DNA synthesis had no effect on the methylation pattern. The role of viral proteins in this inhibition of internal methylation and the significance of the inhibition are discussed.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006288446

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Jordahl, J.L.; Karlen, D.L., 1993: Comparison of alternative farming systems. III. Soil aggregate stability. Quantitative studies are needed to separate the real and supposed benefits of alternative farming practices. Our objective was to learn how conventional and alternative practices on adjacent farms in central Iowa affected the water stability of so...

Green, ED.; Turner, ML.; Baker, C., 2000: Micromorphological specializations of the chicken head louse Cuclotogaster heterographus. Microscopy Society of Southern Africa Proceedings, 30: 66

Tudor, C.; Oproiu, C.; Oproiu, A., 1988: Upper digestive hemorrhage in portal hypertension. Revista de Medicina Interna, Neurologe, Psihiatrie, Neurochirurgie, Dermato-Venerologie. Medicina Interna 40(4): 367-373

Şıklar, Z.; Berberoğlu, M., 2014: Syndromic disorders with short stature. Short stature is one of the major components of many dysmorphic syndromes. Growth failure may be due to a wide variety of mechanisms, either related to the growth hormone (GH)/insulin-like growth factor axis or to underlying unknown pathologies. I...

Richner, J.; Gerber, H.A.; Locher, G.W.; Goldhirsch, A.; Gelber, R.D.; Gullick, W.J.; Berger, M.S.; Groner, B.; Hynes, N.E., 1990: c-erbB-2 protein expression in node negative breast cancer. We investigated the expression of c-erB-2 protein in two matched groups of breast cancer patients, one with and one without relapse. 37 patients with relapse were compared with 42 patients without recurrence for time of observation, adjuvant treat...

Nelson, J., 1978: 22 programmes of community participation in education. The projects listed were selected on the basis not of educational innovation but community participation. Concern for the poorest of the poor and for women were also important criteria. The 22 worldwide programmes may be divided into the following...

Drehmer, D.Leila.; de Aguiar, A.Melo.; Brandt, A.Paula.; Petiz, L.; Cadena, Sílvia.Maria.Suter.Correia.; Rebelatto, C.K.; Brofman, P.R.S.; Filipak Neto, F.; Dallagiovanna, B.; Abud, A.Paula.Ressetti., 2016: Metabolic switches during the first steps of adipogenic stem cells differentiation. NlmCategory="UNASSIGNED">The understanding of metabolism during cell proliferation and commitment provides a greater insight into the basic biology of cells, allowing future applications. Here we evaluated the energy and oxidative cha...

Shabman, L., 1997: Making benefit estimation useful: lessons from flood control experience. Water resources update mn (109) 19-24

Kitada, S.; Takayama, S.; Deriel, K.; Stein, C.A.; Reed, J.C., 1994: Reduction of chemoresistance and induction of apoptosis by antisense downregulation of bcl-2. Proceedings of the American Association for Cancer Research Annual Meeting 35(0): 318

Maguire, K.P.; Burrows, G.D.; Norman, T.R.; Scoggins, B.A., 1978: A radioimmunoassay for nortriptyline (and other tricyclic antidepressants) in plasma. The radioimmunoassay for nortriptyline described here can detect as little 1 microgram/liter of plasma. Within-day precision and day-to-day precision (CV) were +/- 6 and +/- 11%, respectively, over the concentration range 100-200 microgram/liter....