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Regulation of herpesvirus macro molecular synthesis part 7 inhibition of internal methylation of messenger rna late in infection

, : Regulation of herpesvirus macro molecular synthesis part 7 inhibition of internal methylation of messenger rna late in infection. Virology 85(1): 146-156

Previous reports showed that herpes simplex virus RNA entering the cytoplasm has a terminal oligonucleotide structure consistent with 7mG(5')ppp-(5')XmpYmpNp and that, whereas the viral RNA made early in infection contained methylated mononucleotides, the RNA made late did not. This paper reports the following: viral and host [human epidermoid carcinoma HEp-2 cells] adenylated RNA made early in infection were methylated at both the 5' terminus and internally (6mAp); until the RNA made before the onset of synthesis of viral DNA, viral and host adenylated RNA entering the cytoplasm late in infection during the synthesis of .gamma. (structural) polypeptides were methylated at the 5' terminus but not internally; the cessation of methylation of internal nucleotides was not due to rapid turnover of the enzyme(s) responsible for this function; addition of canavanine at any time after infection and until shortly after onset of .beta.-polypeptide synthesis precluded this cessation of internal methylation of host and viral RNA; inhibition of viral DNA synthesis had no effect on the methylation pattern. The role of viral proteins in this inhibition of internal methylation and the significance of the inhibition are discussed.

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