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Regulation of heterologous immuno globulin m immuno globulin g and immuno globulin a antibody responses in mucosal associated lymphoid tissues of nippostrongylus brasiliensis infected mice






Journal of Immunology 130(1): 435-441

Regulation of heterologous immuno globulin m immuno globulin g and immuno globulin a antibody responses in mucosal associated lymphoid tissues of nippostrongylus brasiliensis infected mice

Systemic immunodepression has been studied in many parasitic infections, but little work has been done on modulation of immune responses at mucosal surfaces where local effects, e.g., secretory IgA, may be more relevant to survival of parasites resident at these sites. The modulation of heterologous IgM, IgG and IgA plaque-forming cell (PFC) responses in mucosal-associated tissues was studied in mice infected with the gut nematode, N. brasiliensis. A T-dependent, primary antibody response to trinitrophenyl-bovine .gamma.-globulin (TNP-BGG) was maximally depressed when infection preceded immunization by 5 days. This depression persisted over the complete course of the immune response, affected all 3 isotypes, and was most pronounced in the mucosal-associated lymphoid tissues (mesenteric lymph node (MLN) and bronchial lymph node (BLN)) rather than spleen. In addition to depression of the primary response, generation of IgG and IgA memory cells was also depressed with, by contrast, some evidence to enhancement of IgM memory. The effect of N. brasiliensis infection on T-independent responses was markedly different. Primary responses to DNP-Ficoll were not depressed, with IgM responses unchanged; IgA, and to a lesser extent IgG, anti-DNP responses were significantly elevated in MLN and spleen. This pattern of modulation of antibody responses suggests that helper T cell function at mucosal sites may be defective in N. brasiliensis-infected mice. Such mucosal immunosuppression may facilitate extended parasite survival times in the host.


Accession: 006288451



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