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Regulation of hexo kinase and phospho fructo kinase by testosterone in androgen sensitive tissues


, : Regulation of hexo kinase and phospho fructo kinase by testosterone in androgen sensitive tissues. Voprosy Meditsinskoi Khimii 28(4): 27-30

Possible regulatory effect of testosterone on hexokinase and phosphofructokinase activities was studied in rats seminal vesicles and prostate gland, cAMP, but not cGMP, stimulated the testosterone induction of these enzymes in androgen-sensitive tissues. Cooperative increase in efficiency, observed after simultaneous administration of testosterone and inhibitors of phosphodiesterase, suggested the possible mechanism of cyclonucleotide-mediated regulation of enzymes by androgens. Regulation of the key enzymes appears to be carried out via 2 mechanisms: binding with androgen receptors of cytosol and an increase of intracellular cAMP concentration apparently by means of phosphodiesterase inhibition.

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