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Regulation of histamine release using ionic flux


, : Regulation of histamine release using ionic flux. Anales de la Real Academia de Farmacia 52(4): 741-746

In the present work, mast cells of pleural and peritoneal cavities were treated by several agents which interferes ionic fluxes through membrane such as ATP (Na+ and K+ fluxes) and ruthenium red (Ca2+ flux). We found different behaviour in mast cells of both cavities. This effect was studied in comparison with the inhibitory response induced by isoproterenol on 48/80-induced histamine release in rat mast cells.

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