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Regulation of homo cysteine metabolizing enzymes in aspergillus nidulans


, : Regulation of homo cysteine metabolizing enzymes in aspergillus nidulans. Molecular and General Genetics 155(1): 109-112

Mutants of A. nidulans blocked in the main pathway of cysteine synthesis show an elevated level of the enzymes involved in the synthesis of cysteine from homocysteine, i.e., cystathionine .beta.-synthase [EC 4.2.1.22] and .gamma.-cystathionase and a depressed level of homocysteine methyltransferase [EC 2.1.1.14]. This results in a considerable change in the sulfur amino acids pool as compared to the wild type. Upon addition of cysteine to the growth medium the 1st 2 enzymes are repressed while the level of the 3rd increases. These data indicate that the 2 diverging pathways of homocysteine metabolism are anti-coordinately regulated.

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