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Regulation of homo cysteine metabolizing enzymes in aspergillus nidulans


, : Regulation of homo cysteine metabolizing enzymes in aspergillus nidulans. Molecular and General Genetics 155(1): 109-112

Mutants of A. nidulans blocked in the main pathway of cysteine synthesis show an elevated level of the enzymes involved in the synthesis of cysteine from homocysteine, i.e., cystathionine .beta.-synthase [EC 4.2.1.22] and .gamma.-cystathionase and a depressed level of homocysteine methyltransferase [EC 2.1.1.14]. This results in a considerable change in the sulfur amino acids pool as compared to the wild type. Upon addition of cysteine to the growth medium the 1st 2 enzymes are repressed while the level of the 3rd increases. These data indicate that the 2 diverging pathways of homocysteine metabolism are anti-coordinately regulated.

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Related references

Paszewski A.; Grabski J., 1974: Regulation of sulfur amino acid biosynthesis in aspergillus nidulans role of cysteine and or homo cysteine as regulatory effectors. Molecular & General Genetics 132(4): 307-320

Nadolska-Lutyk, J.; Balinska, M.; Paszewski, A., 1989: Interrelated regulation of sulphur-containing amino-acid biosynthetic enzymes and folate-metabolizing enzymes in Aspergillus nidulans. In Aspergillus nidulans homocysteine can be metabolized both to cysteine and methionine. Mutants impaired in the main pathway of cysteine synthesis or in the sulphate assimilation pathway show a low pool of glutathione and elevated levels of homoc...

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