EurekaMag.com logo
+ Translate

Regulation of human cyto toxic lymphocyte responses 2. suppression by a soluble factor produced by primed lymphocytes


, : Regulation of human cyto toxic lymphocyte responses 2. suppression by a soluble factor produced by primed lymphocytes. Immunology 43(1): 19-24

A soluble supernatant factor is elaborated from in vitro primed human allogeneic lymphocytes which suppresses the development of alloreactive cytotoxic T lymphocytes (CTL). Supernatants obtained from primary mixed lymphocyte cultures (MLC) and primed autologous cultures were unable to suppress CTL activation, indicating that antigen restimulation was required to elicit the factor. The suppressor factor (SF) functioned in a dose-dependent manner. When the SF was added 24 or 48 h after MLC initiation it was ineffective. Adding the SF at culture initiation significantly reduced CTL activity, suggesting that suppression occurs either during antigen recognition or early in the CTL differentiation pathway. The SF did not function by altering the CTL response kinetics. Preincubation experiments showed that the SF operates by partially inactivating both MLC responder and stimulator cell populations.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006288517

PMID: 6454647

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Luger, S.W., 1990: Possible Lyme carditis--not definite. Archives of Internal Medicine 150(8): 1755-1755

Ishikawa, T.; Kobayashi, M.; Yanagi, S.; Kato, C.; Takashima, R.; Kobayashi, E.; Hagiwara, K.; Ochiya, T., 2016: Human induced hepatic lineage-oriented stem cells: autonomous specification of human iPS cells toward hepatocyte-like cells without any exogenous differentiation factors. Preparing targeted cells for medical applications from human induced pluripotent stem cells (hiPSCs) using growth factors, compounds, or gene transfer has been challenging. Here, we report that human induced hepatic lineage-oriented stem cells (hi...

Anderson, W.; Flowerday, A., 1973: Summer jobs in ag careers. Summer 22 (2) 11

Rosen D., 1981: Pseudaphycus debachi new species hymenoptera encyrtidae with notes on the pseudaphycus angelicus group. Pseudaphycus Clausen and related genera are considered to belong in the subfamily Tetracneminae. P. debachi sp. nov., a parasite of the striped mealybug Ferrisia virgata (Cockereli) from Mexico, is described and compared morphologically to several...

Fernandez, R.; Oliveira-Souza, M.; Malnic, G., 2001: Na+-independent proton secretion in MDCK-C11 cells. In this work we studied the proton secretion mechanisms in recently cloned MDCK-C11 cells. We measured intracellular pH (pHi) in monolayers grown on permeable filters, using the pH-sensitive probe BCECF and an inverted epifluorescence microscope....

Takemoto, Y.; Suzuki, Y.; Horibe, R.; Shimozawa, N.; Wanders, R.J.A.; Kondo, N., 2003: Gas chromatography/mass spectrometry analysis of very long chain fatty acids, docosahexaenoic acid, phytanic acid and plasmalogen for the screening of peroxisomal disorders. Very long chain fatty acids (VLCFAs) and docosahexaenoic acid (DHA), phytanic acid, and plasmalogens are usually measured individually. A novel method for the screening of peroxisomal disorders, using gas chromatography/mass spectrometry (GC/MS),...

Marcuard S.P.; Silverman J.F.; Finley J.L.; Castellani W.J.; Khazanie P.G., 1988: Detrimental effect of a protein free diet on gastric ulcer gu histology. Gastroenterology 94(5 PART 2): A282

Pawan Kumar; Pramod K.S.ngh; Bhaskar Bhattacharya, 2011: Study of nano-CdS prepared in methanolic solution and polymer electrolyte matrix. This present paper reports the study of cadmium sulphide (CdS) nanoparticles prepared under controlled condition in methanolic solution and also in polyethylene oxide polymer electrolyte matrix. The sulphurations of the cadmium salts were done in...

Kusnetsova, M.; Zusag, T.; Chen, W.; Wang, X.; Virudachalam, R., 1994: Dosimetric consequences of blocking strategy and vaginal geometry in the definitive irradiation of carcinoma of the cervix. International Journal of Radiation Oncology Biology Physics 30(SUPPL 1): 286

Alani, A.M.; Faramarzi, A.; Mahmoodian, M.; Tee, K.Fah., 2014: Prediction of sulphide build-up in filled sewer pipes. Millions of dollars are being spent worldwide on the repair and maintenance of sewer networks and wastewater treatment plants. The production and emission of hydrogen sulphide has been identified as a major cause of corrosion and odour problems in...