EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of human cyto toxic lymphocyte responses 2. suppression by a soluble factor produced by primed lymphocytes






Immunology 43(1): 19-24

Regulation of human cyto toxic lymphocyte responses 2. suppression by a soluble factor produced by primed lymphocytes

A soluble supernatant factor is elaborated from in vitro primed human allogeneic lymphocytes which suppresses the development of alloreactive cytotoxic T lymphocytes (CTL). Supernatants obtained from primary mixed lymphocyte cultures (MLC) and primed autologous cultures were unable to suppress CTL activation, indicating that antigen restimulation was required to elicit the factor. The suppressor factor (SF) functioned in a dose-dependent manner. When the SF was added 24 or 48 h after MLC initiation it was ineffective. Adding the SF at culture initiation significantly reduced CTL activity, suggesting that suppression occurs either during antigen recognition or early in the CTL differentiation pathway. The SF did not function by altering the CTL response kinetics. Preincubation experiments showed that the SF operates by partially inactivating both MLC responder and stimulator cell populations.

(PDF 0-2 workdays service: $29.90)

Accession: 006288517

PMID: 6454647



Related references

Specific in vitro suppression of both the mixed lymphocyte culture responder function and the generation of cyto toxic t lymphocytes by soluble factor present in human and pig liver extracts. European Surgical Research 12(SUPPL 1): 76, 1980

T t cell interactions during cyto toxic t lymphocytes responses t cell derived helper factor interleukin 2 as a probe to analyze cyto toxic t lymphocyte responsiveness and thymic maturation of cyto toxic t lymphocyte progenitors. Moller, G (Ed ) Immunological Reviews, Vol 51 T Cell Stimulating Growth Factors 357p Munksgaard: Copenhagen, Denmark Illus Paper P215-256, 1980

The generation of cyto toxic lymphocytes requires soluble helper factor produced in response to lymphocyte defined antigens. Federation Proceedings 37(6): 1557, 1978

Regulation of human cyto toxic lymphocyte responses 1. noncytolytic suppression mediated by allo antigen activated cells. Immunology 43(1): 11-18, 1981

Resistance of nzb and cba cyto toxic lymphocyte responses to suppression by soluble factors from allo antigen sensitized spleen cells. Federation Proceedings 38(3 PART 1): 1182, 1979

In vivo differentiation of cyto toxic t lymphocytes 1. serum factor in immunized athymic nu nu mice could differentiate cyto toxic t lymphocyte precursor. Immunobiology 166(2): 212-218, 1984

Suppression of lymphocyte proliferative and cyto toxic responses by human tumor associated immuno regulatory factors. Immunobiology 159(1-2): 190, 1981

Immuno regulation by mouse t cell clones 1. suppression and amplification of cyto toxic responses by cloned h y specific cytolytic t lymphocytes. Cellular Immunology 86(1): 206-221, 1984

Human cyto toxic t lymphocytes induced by phyto hem agglutinin conditions for cyto toxic t lymphocyte generation and effect of interferon. Japanese Journal of Medical Science & Biology 35(5-6): 221-230, 1982

Effect of cyclosporin a on human lymphocyte responses in vitro 3. cyclosporin a inhibits the production of t lymphocyte growth factors in secondary mixed lymphocyte responses but does not inhibit the response of primed lymphocytes to t cell growth factor. Journal of Immunology 128(1): 355-359, 1982