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Regulation of human cyto toxic lymphocyte responses 2. suppression by a soluble factor produced by primed lymphocytes

, : Regulation of human cyto toxic lymphocyte responses 2. suppression by a soluble factor produced by primed lymphocytes. Immunology 43(1): 19-24

A soluble supernatant factor is elaborated from in vitro primed human allogeneic lymphocytes which suppresses the development of alloreactive cytotoxic T lymphocytes (CTL). Supernatants obtained from primary mixed lymphocyte cultures (MLC) and primed autologous cultures were unable to suppress CTL activation, indicating that antigen restimulation was required to elicit the factor. The suppressor factor (SF) functioned in a dose-dependent manner. When the SF was added 24 or 48 h after MLC initiation it was ineffective. Adding the SF at culture initiation significantly reduced CTL activity, suggesting that suppression occurs either during antigen recognition or early in the CTL differentiation pathway. The SF did not function by altering the CTL response kinetics. Preincubation experiments showed that the SF operates by partially inactivating both MLC responder and stimulator cell populations.

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