EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of human granulocyte function by products derived from murine tumors


Experimental Hematology 13(2): 151-156
Regulation of human granulocyte function by products derived from murine tumors
Murine EL-4 thymoma was found to produce a factor that activated antibody-dependent cell-mediated cytotoxicity by human eosinophils and neutrophils. The eosinophil-activating factor had some properties similar to human eosinophil colony-stimulating factor in being heat stable, inactivated by 2-mercaptoethanol, and cochromatographing by gel filtration with a factor that promoted the growth of pure eosinophil colonies from human bone marrow. The neutrophil-activating factor from EL-4 was also heat stable but was not inactivated by 2-mercaptoethanol and was found in two peaks on chromatography, neither having human neutrophil-CSF activity but one cochromatographing with mouse granulocyte-macrophage CSF. EL-4 therefore secretes factors that activate two types of human granulocytes. Several other murine thymomas and macrophage cell lines produced a neutrophil-activating factor, the production of which could not be correlated with that of several other known lymphokines. Murine tumors produce factors that activate human granulocytes.


Accession: 006288526

PMID: 3871706



Related references

Effects of monocyte- and macrophage-derived products on granulocyte function in asthma. International Archives of Allergy and Applied Immunology 90 Suppl 1: 64-69, 1989

Susceptibility of human and murine Chlamydia trachomatis serovars to granulocyte- and epithelium-derived antimicrobial peptides. Journal of Peptide Research 61(5): 237-242, May, 2003

Susceptibility of human and murine Chlamydia trachomatis serovars to granulocyte- and epithelium-derived antimicrobial peptides. Journal of Peptide Research 61(5): 237-242, 2003

Non thymus derived cell mediated cyto toxicity in mice with tumors induced by moloney murine sarcoma virus 2. granulocyte mediated cyto toxicity against autochthonous target cells isolated from moloney murine sarcoma virus induced tumors. Journal of the National Cancer Institute 65(2): 469-476, 1980

Cyclic amp and the regulation of human granulocyte function. Journal Of Clinical Investigation: 11a-12a, 1970

A monoclonal antibody specific to the granulocyte-derived elastase-fragment D species of human fibrinogen and fibrin: its application to the measurement of granulocyte-derived elastase digests in plasma. Blood 95(5): 1721-1728, 2000

Human granulopoiesis in vitro--medium-dependent growth regulation by a granulocyte-derived inhibitor. Acta Physiologica Scandinavica 133(1): 41-47, 1988

In vitro assessment of the effects of granulocyte-macrophage colony-stimulating factor on primary human tumors and derived lines. Cancer Research 50(19): 6264-6267, 1990

Regulation of NK cell function by human granulocyte arginase. Journal of Immunology 182(9): 5259-5267, 2009

Newer aspects of regulation of human granulocyte function. Australian and New Zealand Journal of Medicine 14(1): 71-74, 1984