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Regulation of human histone gene expression kinetics of accumulation and changes in the rate of synthesis and in the half lives of individual histone messenger rna during the hela cell cycle


, : Regulation of human histone gene expression kinetics of accumulation and changes in the rate of synthesis and in the half lives of individual histone messenger rna during the hela cell cycle. Molecular & Cellular Biology 3(4): 539-550

The kinetics of accumulation of each of the individual core histone mRNA throughout the HeLa cell cycle were analyzed in cells synchronized by sequential thymidine and aphidicolin treatments. During the S phase, there was a 15-fold increase in the levels of histone mRNA and this resulted from both an increased rate of synthesis and a lengthening of the half-life of histone mRNA. A comparison of the kinetics of accumulation of histone mRNA in the total cellular and nuclear RNA populations suggested an increased transcription rate through the S phase. Within 30 min after the inhibition of DNA synthesis in mid-S phase, the steady-state concentration and the rate of synthesis of histone mRNA each declined to their non-S-phase levels. Reactivation of histone mRNA accumulation could occur even after an extended mid-S-phase block in DNA synthesis. The mechanisms responsible for histone mRNA synthesis are not restricted to the G1/S boundary of the HeLa cell cycle, but can operate whenever DNA synthesis is occurring.

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