+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of human jejunal glycolytic enzymes by oral folic acid

, : Regulation of human jejunal glycolytic enzymes by oral folic acid. Journal of Clinical Investigation 48(11): 2038-2045

The effect of oral folic acid on jejunal glycolytic enzyme activity in five fasting obese patients and in three normal male volunteers on a constant 3000 cal diet was studied. The glycolytic enzymes, fructokinase, hexokinase, glucokinase, fructose-1-phosphate aldolase, and fructose diphosphate aldolase, and the disaccharidases, sucrase, maltase, and lactase were measured. In both the fasting patients and the normal volunteers, oral folic acid significantly increased the jejunal glycolytic enzyme activities but had no effect on disaccharidase activity. When oral folic acid was discontinued in the normal volunteers, the glycolytic enzyme activities returned to control values. In the obese patients, refeeding and folic acid caused a further increase in glycolytic enzyme activities above that seen with fasting and folic acid. In contrast to oral folic acid, intramuscular folic acid, oral vitamin B(12), and oral tetracycline had no effect on glycolytic enzyme activities. These studies demonstrate that oral folic acid which is neither a substrate nor a coenzyme of these enzymes, increases human jejunal glycolytic enzyme activity in a specific fashion. This would appear to be an action of oral folic acid which has not been recognized previously.

(PDF same-day service: $19.90)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006288544

PMID: 5824069

DOI: 10.1172/JCI106169

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Bagarello V.; Iovino M.; Palazzolo E.; Panno M.; Reynolds W. D., 2006: Field and laboratory approaches for determining sodicity effects on saturated soil hydraulic conductivity. Dilution of high-sodicity soil water by low-sodicity rainfall or irrigation water can cause declining soil hydraulic conductivity (K) by inducing swelling, aggregate slaking and clay particle dispersion. Investigations of sodicity-induced reductio...

Mathur A.; Kamat D.M.; Van Ness B.G.; Lynch R.G., 1987: Thymus dependent in vivo suppression of ige synthesis in a murine ige secreting hybridoma. In previous studies we demonstrated that BALB/c mice bearing ascitic tumors of the IgE-secreting hybridoma B53 (.epsilon., .kappa., anti-dinitrophenyl) developed large numbers of Lyt-1-2+ Fc.epsilon. R(+) T lymphocytes (T cells with membrane Fc re...

Malyarevskaya, AYa.; Birger, TI.; Komarovskij, FYa., 1978: Determination of blue green algae toxins accumulation in fish tissue. Unknown

McBride, R.; Greig, D.; Travisano, M., 2008: Fungal viral mutualism moderated by ploidy. Endosymbionts and their hosts have inherently ambiguous relationships as symbionts typically depend upon their hosts for shelter, nutrition, and reproduction. Endosymbionts can acquire these needs by two alternative strategies: exploitation and co...

Soo, A.W.; Parissis, H., 2013: Transthoracic intra-aortic balloon pump removal without repeat sternotomy. Transaortic balloon catheter insertion for intra-aortic balloon assistance is a practical alternative to the standard transfemoral cannulation in patients with significant aortoiliac occlusive disease. We describe a technique whereby a transthorac...

Speckmann E J., 1979: Inter ictal epicortical seizure activity and its relation to spinal field potentials in the rat. Epilepsia: 180-181

Vu, K.; Busaidy, N.; Cabanillas, M.E.; Konopleva, M.; Faderl, S.; Thomas, D.A.; O'Brien, S.; Broglio, K.; Ensor, J.; Escalante, C.; Andreeff, M.; Kantarjian, H.; Lavis, V.; Yeung, S-Ching.Jim., 2013: A randomized controlled trial of an intensive insulin regimen in patients with hyperglycemic acute lymphoblastic leukemia. Hyperglycemia during hyper-CVAD (fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with methotrexate and high-dose cytarabine, with methylprednisolone premedication) chemotherapy is associated with poor outcome...

De Coster R.; Beerens D.; Haelterman C.; Wouters L., 1985: Effects of etomidate on cortisol biosynthesis in isolated guinea pig adrenal cells comparison with metyrapone. The effects of the iv hypnotic etomidate on cortisol biosynthesis have been investigated in short term incubations of dispersed guinea-pig adrenal cells and were compared with those produced by metyrapone. Fifty per cent inhibition of cortisol out...

Sumrall, A.J.; Johnson, W.C., 1973: The origin of dermal fibrocytes in wound repair. Dermatologica 146(2): 107-114

Lazo, A.; Wilner, H.I.; Metes, J.J., 1981: Craniofacial mucormycosis: computed tomographic and angiographic findings in two cases. Cases are reported in a 30-yr-old woman kidney transplant patient receiving immunosuppressive therapy and in a 31-yr-old diabetic man. Computed tomographic and angiographic findings are presented.