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Regulation of human lipolysis. In vivo observations on the role of adrenergic receptors


, : Regulation of human lipolysis. In vivo observations on the role of adrenergic receptors. Journal of Clinical Investigation 53(1): 338-341

Changes in the plasma free fatty acids of a pancreatectomized subject and in free fatty acids and insulin in 10 normal subjects in response to the in vivo infusion of epinephrine alone, epinephrine plus phentolamine, and epinephrine plus propranolol indicate that both alpha and beta adrenergic receptors are present in human adipose tissue. Under the experimental conditions used, adipose tissue appeared to be more responsive to epinephrine than did the cardiovascular system.

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Accession: 006288548

PMID: 4808646

DOI: 10.1172/JCI107556

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Related references

Mohs J.M.; Langley P.E.; Chase G.; Yawn R.; Burns T.W., 1973: In vivo observations on the role of adrenergic receptors in the regulation of human lipolysis. Diabetes 22(SUPPL 1): 324

Mohs J.M.; Langley P.E.; Chase G.R.; Burns T.W., 1972: In vivo observations on the role of alpha adrenergic receptor site and beta adrenergic receptor sites in human lipolysis. Clinical Research 20(1): 57

Berlan, M.; Lafontan, M.; Dang Tran, L., 1980: Adrenergic lipolysis in human fat cells: properties and physiological role of alpha-adrenergic receptors. Lipolytic activity of human isolated fat cells from different fat deposits was studied. The purpose of the present investigations was to determine the epinephrine responsiveness, with regard to alpha- and beta-adrenergic receptor site activity, of...

Kucio, C.; Zahorska-Markiewicz, B., 1985: Role of adrenergic receptors in the regulation of lipolysis and in the pathogenesis of obesity. Polski Tygodnik Lekarski 40(50): 1411-1414

Burns, T.W.; Langley, P.E.; Robison, G.A., 1971: Adrenergic receptors and cyclic AMP in the regulation of human adipose tissue lipolysis. Annals of the New York Academy of Sciences 185: 115-128

Hagstrom Toft, E.; Enoksson, S.; Moberg, E., 1998: B-adrenergic regulation of lipolysis and blood flow in human skeletal muscle in vivo. Little is known about the regulation of catecholamine-stimulated lipolysis in human skeletal muscle. Therefore, b-adrenergic regulation of lipolysis and blood flow was investigated in healthy subjects in vivo by use of microdialysis of the gastroc...

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Pecquery, R.; Leneveu, M.C.; Giudicelli, Y., 1983: Characterization of the beta-adrenergic receptors of hamster white fat cells. Evidence against an important role for the alpha 2-receptor subtype in the adrenergic control of lipolysis. The binding characteristics of the beta-adrenergic antagonist, [3H]dihydroalprenolol, to hamster white adipocyte membranes were studied. This binding occurred at two classes of sites, one having high affinity (Kd = 1.6 +/- 1.3 nM) but low capacity...

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