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Regulation of human natural killing 1. the role of monocytes interferon and prostaglandins

, : Regulation of human natural killing 1. the role of monocytes interferon and prostaglandins. Journal of Immunology 127(5): 2007-2013

Human endogenous natural killer (NK) activity as measured in a rapid 51Cr release assay is unaffected by the presence of monocytes. Stimulation of NK cells by poly I:C is independent of monocytes. The presence of monocytes in a mixed population of mononuclear cells that were stimulated by poly I:C suppresses NK activity. The suppresion is partially reversible if indomethacin (10-6 M) is added to the cultures during stimulation. Culture supernatants of monocytes stimulated with poly I:C contain prostaglandin E1 (PGE1), as shown by radioimmunoassay, and have NK inhibitory activity comparable to that obtained with exogenous PGE1 added to NK assays at a concentration range of 10-7-10-9 M. Culture supernatants from poly I:C-stimulated monocytes do not have detectable levels of antiviral activity. Plastic nonadherent cells stimulated with poly I:C produce significant levels of interferon (100-200 U/ml per 2 .times. 106 cells) but almost undetectable amounts of PGE. Supernatants of nonadherent cells incubated with indomethacin (10-6 M) alone augment NK activity. Thus, stimulation of mononuclear cells with poly I:C is dependent on the regulated by the relative levels of interferon produced by lymphocytes and PGE produced by monocytes.

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