EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of humoral immune responses by a bone marrow derived glyco lipid like molecule






Cellular Immunology 71(2): 293-302

Regulation of humoral immune responses by a bone marrow derived glyco lipid like molecule

Bone marrow cells nonspecifically suppress primary in vitro antibody responses. This suppression appears to be mediated by a low-MW soluble factor, B-SF [B-suppresser factor] which was released from a fraction of cells of similar size to the suppressor as obtained by velocity sedimentation. Like the suppressor cell, B-SF was effective very early in the immune response. It was produced by all strains of mice tested and functioned across strain barriers. Characterization of the active suppressor molecule showed it to be a highly heat-stable, nonsialic acid-containing glycolipid of 1000-35,000 daltons MW. Recovery of the purified suppressor from TLC plates was achieved indicating that the major glycolipid component visualized on TLC is likely the active suppressor molecule. The characteristics of this suppressor may show it to be a fundamental immune regulatory mechanism.


Accession: 006288593

PMID: 6215990



Related references

Esselman, W.J.; Miller, H.C., 1977: Modulation of bone marrow derived cell responses by glyco lipid released from antigen stimulated thymus derived cells. Mice immunized with 109 or 106 SRBC [sheep erythrocytes] were used as a source of T [thymus-derived] suppressor (Ts) cells and T helper (Th) cells, respectively. T cells were prepared by purification on glass wool and nylon wool columns and were c...

Katz D.H., 1973: Genetic requirements for physiologic cooperative interactions between thymus derived and bone marrow derived lymphocytes in humoral immune responses. Journal of General Physiology 62(5): 651

Stockinger B.; Botzenhardt U.; Lemmel E.M., 1979: On the feedback regulation of humoral immune response part 1 evidence for bone marrow derived suppressor cells. Complete and antigen-specific immune inhibition can be obrained by B [bone marrow-derived] suppressor cells. Transfer of spleen cells from twice-immunized (SRBC [sheep red blood cell]) [mice] to untreated syngeneic recipients resulted in antigen-s...

Isakov N.; Hollander N.; Segal S.; Feldman M., 1979: Factor originating in spleen cells of tumor bearing mice augments humoral immune responses by direct activation of bone marrow derived lymphocytes. Israel Journal of Medical Sciences 15(2): 183-184

Anderson, R.E.; Standefer, J.C.; Scaletti, J.V., 1977: The phospho lipid and glyco protein composition of thymus derived and bone marrow derived cells. Cell surface components were isolated from BALB/c thymocytes, nu/nu spleen cells and BALB/c spleen cells. These components were analyzed for: cholesterol esters; total and individual phospholipids; individual fatty acids from 1 and 2 positions of...

Lee, J.Kil.; Schuchman, E.H.; Jin, H.Kyung.; Bae, J-sung., 2012: Soluble CCL5 derived from bone marrow-derived mesenchymal stem cells and activated by amyloid β ameliorates Alzheimer's disease in mice by recruiting bone marrow-induced microglia immune responses. Microglia have the ability to eliminate amyloid β (Aβ) by a cell-specific phagocytic mechanism, and bone marrow (BM) stem cells have shown a beneficial effect through endogenous microglia activation in the brains of Alzheimer's disease (AD)...

Nilsson, K.; Andersson, L.C.; Gahmberg, C.G.; Wigzell, H., 1977: Surface glyco protein patterns of normal and malignant human lymphoid cells part 2 bone marrow derived cells bone marrow derived blasts and epstein barr virus positive and negative bone marrow derived lymphoid cell lines. Surface glycoproteins of normal human B [bone marrow-derived] lymphocytes, B blasts and various types of lymphoid cell lines were labeled by the galactose oxidase-3H4-NaB method. The labeled glycoproteins were separated by polyacrylamide slab gel...

Segre, D.; Segre, M., 1977: Age related changes in bone marrow derived and thymus derived lymphocytes and decline of humoral immune responsiveness in aged mice. The activity of the immune system declines in an age-related fashion, after reaching a peak in young-adult animals. The mechanisms responsible for the decline of immune potential in senescence are not fully elucidated. The immune response depends...

Rosenstreich, D.L.; Asselineau, J.; Mergenhagen, S.E.; Nowotny, A., 1974: A synthetic glyco lipid with bone marrow derived cell mitogenic activity. Journal of Experimental Medicine 140(5): 1404-1409

Hoiby N.; Mathiesen L., 1974: Pseudomonas aeruginosa infection in cystic fibrosis distribution of bone marrow derived and thymus derived lymphocytes in relation to the humoral immune response. Acta Pathologica et Microbiologica Scandinavica Section B Microbiology & Immunology 82(4): 559-566