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Regulation of hydrogen per oxide in eye humors effect of 3 amino 1h 1 2 4 triazole on catalase ec and glutathione peroxidase ec of rabbit eye

, : Regulation of hydrogen per oxide in eye humors effect of 3 amino 1h 1 2 4 triazole on catalase ec and glutathione peroxidase ec of rabbit eye. Biochimica et Biophysica Acta 497(3): 641-651

Activities of catalase (H2O2:H2O2 oxidoreductase, EC and GSH [glutathione] peroxidase (GSH:H2O2 oxidoreductase, EC were measured in iris, ciliary body, retina, corneal epithelium, corneal endothelium, lens capsule-epithelium and decapsulated lens. 3-Amino-1H-1,2,4-triazole is a specific inhibitor of catalase and a potent cataractogenic agent. There was marked inhibition of catalase activity in these tissues 1-6 h after the administration of a single i.v. dose of 1 g 3-aminotriazole/kg body weight in rabbit. This was associated with a 2-3-fold increase in the H2O2 concentrations of aqueous humor and vitreous humor. The increased peroxide concentrations were restored to the physiological levels as the catalase activity of eye tissues gradually returned to normal with time after injection. Under the conditions, GSH peroxidase activity of the aforementioned eye tissues was unaltered, GSH and protein sulfhydryl of lens were not changed, and ascorbic acid of aqueous humor and vitreous humor was not significantly altered. Catalase of eye tissues apparently regulates the endogenous H2O2 in eye humors to the physiological level. H2O2 may be the triggering factor in cataract induced by 3-aminotriazole.

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Hoffmann Richard L., 1984: Microcomputer applications for Devonian shale and other producers. Pages 15-16 1984

Ezekwo G.; Tong H M.; Gryte C.C., 1980: The mechanism of de watering colloidal aqueous solutions by freeze thaw processes. Domestic sewage sludge of different solids content was solidified by crystallization in a temperature gradient. Thermal analysis showed that the segregated solute matrix contained about 50% water after freezing. The morphology of the segregated ic...

STALDER.G.; SCHMID.R., 1959: Severe functional disorders of glomerular capillaries and renal hemodynamics in treated diabetes mellitus during childhood. Renal clearance studies in diabetic children reveal an elevated filtration fraction and glomerular filtration rate, associated with either renal hyperemia or longstanding renal oligemia. The tubular reabsorptive capacity for phosphate is increased...

Bauerova O.; Voticky Z., 1973: Buxus alkaloids part 2 alkaloids from buxus microphylla var sinica. Die Pharmazie 28(3): 212-214

Obinata, T.; Yamamoto, M.; Maruyama, K., 1966: The identification of randomly formed thin filaments in defferentiating muscle cells of the chick embryo. The appearance of thin filaments, 60-80 A in width, in the myoblasts of early chick embryos incubated for 3 days at 39[degree]C was observed with the electron microscope. The filaments were distributed randomly throughout the cytoplasmic matrix of...

Katz, M.L.; Kutryb, M.J.; Norberg, M.; Gao, C.L.; White, R.H.; Stark, W.S., 1991: Maintenance of opsin density in photoreceptor outer segments of retinoid-deprived rats. Dietary deficiency in the retinoid precursors of the visual pigment chromophore 11-cis-retinal eventually results in selective degeneration of the photoreceptor cells of the vertebrate retina. Early effects of retinoid deficiency are depletion of...

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Malak, R.R.; Matar, G.M.; Abdelnoor, A.M., 1997: SDS-PAGE of mononuclear cell protein lysates of HLA-identical twins and HLA non-identical individuals. The loci responsible for the most vigorous graft-rejection reactions are contained within the HLA complex in humans. However, even when a donor and recipient have identical HLA antigens, differences in minor histocompatibility loci outside the maj...

Maniu, A.Aurelia.; Harabagiu, O.; Damian, L.Otilia.; Ştefănescu, E.HoraŢiu.; FănuŢă, B.Marius.; Cătană, A.; Mogoantă, C.Aurelia., 2016: Mastoiditis and facial paralysis as initial manifestations of temporal bone systemic diseases - the significance of the histopathological examination. Several systemic diseases, including granulomatous and infectious processes, tumors, bone disorders, collagen-vascular and other autoimmune diseases may involve the middle ear and temporal bone. These diseases are difficult to diagnose when sympto...

Blicklé, J.F., 2006: Meglitinide analogues: a review of clinical data focused on recent trials. Glinides represent a chemically heterogeneous new class of insulin-secreting agents characterized by a rapid onset and short duration of action. They act by closure of the ATP-dependant K channel. Repaglinide, the only glinide available in France,...