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Regulation of hydrogen per oxide in eye humors effect of 3 amino 1h 1 2 4 triazole on catalase ec 1.11.1.6 and glutathione peroxidase ec 1.11.1.9 of rabbit eye


, : Regulation of hydrogen per oxide in eye humors effect of 3 amino 1h 1 2 4 triazole on catalase ec 1.11.1.6 and glutathione peroxidase ec 1.11.1.9 of rabbit eye. Biochimica et Biophysica Acta 497(3): 641-651

Activities of catalase (H2O2:H2O2 oxidoreductase, EC 1.11.1.6) and GSH [glutathione] peroxidase (GSH:H2O2 oxidoreductase, EC 1.11.1.9) were measured in iris, ciliary body, retina, corneal epithelium, corneal endothelium, lens capsule-epithelium and decapsulated lens. 3-Amino-1H-1,2,4-triazole is a specific inhibitor of catalase and a potent cataractogenic agent. There was marked inhibition of catalase activity in these tissues 1-6 h after the administration of a single i.v. dose of 1 g 3-aminotriazole/kg body weight in rabbit. This was associated with a 2-3-fold increase in the H2O2 concentrations of aqueous humor and vitreous humor. The increased peroxide concentrations were restored to the physiological levels as the catalase activity of eye tissues gradually returned to normal with time after injection. Under the conditions, GSH peroxidase activity of the aforementioned eye tissues was unaltered, GSH and protein sulfhydryl of lens were not changed, and ascorbic acid of aqueous humor and vitreous humor was not significantly altered. Catalase of eye tissues apparently regulates the endogenous H2O2 in eye humors to the physiological level. H2O2 may be the triggering factor in cataract induced by 3-aminotriazole.

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