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Regulation of idiotope expression 1. the effect of antigen dose on expression of certain t 15 idiotopes during primary immunoglobulin m response to streptococcus pneumoniae r 36a


, : Regulation of idiotope expression 1. the effect of antigen dose on expression of certain t 15 idiotopes during primary immunoglobulin m response to streptococcus pneumoniae r 36a. Journal of Immunology 134(3): 1926-1929

Clonal heterogeneity among mouse B cells reactive to the same epitope may be determined through differences in idiotypy. It appears that clones bearing distinct idiotopes may constitute functionally distinct subpopulations. Data suggest that idiotopically distinct clones of PC [phosphocholine]-reactive B cells may be regulated independently of one another. It was determined whether individual T15+ clones may also differ in their requirements for activation. The effect of immunizing doses of antigen on expression of 2 T15 idiotopes, B36-82 and B39-38, during both in vivo and in vitro primary responses to S. pneumoniae R36a (Pn) was examined in CB-20 mouse strain. The idiotopes were detected on the specific antibody plaque-forming cells (PFC) by using monoclonal anti-idiotopic antibodies. Distinct patterns of idiotope expression are generated by stimulation with different doses of antigen. Immunization with suboptimal and superoptimal doses of Pn produced responses dominated by PFC expressing both idiotopes. PFC induced by optimal antigen concentrations were primarily B36-82+ and B39-38-. These data indicate that the varying of antigen concentration may induce the response of different B cells bearing distinct idiotypes.

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