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Regulation of IgA secretion by T cell clones derived from the human gastrointestinal tract

Journal of Immunology 140(6): 1874-1882
Regulation of IgA secretion by T cell clones derived from the human gastrointestinal tract
The role of T cells in Ig isotype regulation is still unclear. To address this question, we generated mitogen-stimulated T cell clones from normal human lymphoid follicles of the gut-associated lymphoid tissue (appendix). Both the T cell clones and clonal supernatants provided preferential help for IgA secretion by PWM-stimulated B cells. Many of these CD3+, CD4+, 4B4+, DR+ helper clones co-expressed Fc-.gamma. and Fc-.alpha.

Accession: 006288631

PMID: 2964487

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