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Regulation of immune response by preadministration of cells briefly pulsed with antigen in vitro 3. functional change of antigen presenting cells

, : Regulation of immune response by preadministration of cells briefly pulsed with antigen in vitro 3. functional change of antigen presenting cells. International Archives of Allergy and Applied Immunology 76(3): 270-274

An i.v. administration of syngeneic spleen cells (SPC) caused the reduction of antigen presenting activity of splenic adherent cells (SAC). The antigen presenting activity of SAC was reduced 10 days after the i.v. injection of 5 .times. 107 antigen pulsed or antigen nonpulsed SPC. When mice were immunized 5 days after the i.v. injection of SPC, antigen presenting activity was reduced in the mice injected with antigen pulsed SPC and not in the mice injected with antigen nonpulsed SPC. This reduction was recovered by the administration of cyclophosphamide 3 days before the injection of antigen pulsed SPC, suggesting that suppressor T cells played an important role in the reduction of antigen presenting activity.

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