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Regulation of immune responses against the syngeneic adj pc 5 plasma cytoma in balb c mice 3. induction of specific t suppressor cells to the balb c plasma cytoma adj pc 5 during early stages of tumorigenesis


, : Regulation of immune responses against the syngeneic adj pc 5 plasma cytoma in balb c mice 3. induction of specific t suppressor cells to the balb c plasma cytoma adj pc 5 during early stages of tumorigenesis. Immunology 47(3): 503-510

Initial stages of tumor growth are not easily accessible to investigation. An experimental procedure was developed to mimic tumorigenesis as closely as possible. BALB/c mice received i.p. exponentially increased numbers of irradiated syngeneic ADJ-PC-5 plasmacytoma cells. The initial injection began with 2 cells per mouse and, according to the generation time of this tumor, subsequent doses were doubled until mice had received up to 105 tumor cells. At various stages of treatment, peritoneal exudate cells (PEC) and spleen cells (SC) were tested for either cytotoxicity or specific suppression of induction of a primary in vitro T-cell cytotoxic response (CTL) of BALB/c spleen cells against ADJ-PC-5 plasmacytoma cells. No cytotoxic PEC were found. PEC from mice in which the final tumor cells number had reached or exceeded 103 irradiated ADJ-PC-5 cells, induced complete suppression of this primary in vitro CTL. Specificity was found both in the induction and effector phase of suppression. Specific suppression was mediated by Thy-1.2+ cells and amplified by nonspecific suppression through adherent cells. The data are discussed in context with findings on the in vivo immunogenicity and tolerogenicity of the ADJ-PC-5 plasmacytoma. Induction of T suppressor (Ts) cells might be an early event in tumorigenesis.

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Haubeck H D.; Koelsch E., 1981: Induction of suppressor cells to the syngeneic plasma cytoma adj pc 5 in balb c mice at early stages of tumorigenesis. Immunobiology 160(1): 40

Haubeck, H.D.; Kölsch, E., 1982: Regulation of immune responses aginst the syngeneic ADJ-PC-5 plasmacytoma in BALB-c mice. III. Induction of specific T suppressor cells to the BALB/c plasmacytoma ADJ-PC-5 during early stages of tumorigenesis. Initial stages of tumour growth are not easily accessible to investigation. Therefore an experimental procedure was developed to mimic tumorigenesis as closely as possible. BALB/c mice received intraperitoneally exponentially increasing numbers of...

Haubeck, H.D.; Kölsch, E., 1986: Regulation of immune responses against the syngeneic ADJ-PC-5 plasmacytoma in BALB/c mice. IV. Tumor-specific T suppressor cells, induced at early stages of tumorigenesis, act on the induction phase of the tumor-specific cytotoxic T cell response. The BALB/c plasmacytoma ADJ-PC-5 induces specific non-cytolytic T suppressor (Ts) cells under experimental conditions which closely resemble early stages of tumorigenesis. The phenotype of these Ts cells is Thy-1.2+, Lyt-1.2-, Lyt-2.2+, I-Ad-. The...

Haubeck, H.D.; Koelsch, E., 1986: Regulation of immune responses against the syngeneic adj pc 5 plasmacytoma in balb c mice iv. tumor specific t suppressor cells induced at early stages of tumorigenesis act on the induction phase of the tumor specific cytotoxic t cell response. The BALB/c plasmacytoma ADJ-PC-5 induces specific non-cytolytic T suppressor (Ts) cells under experimental conditions which closely resemble early stages of tumorigenesis. The phenotype of these Ts cells is Thy-1.2+, Lyt-1.2-, Lyt-2.2+, I-Ad-. The...

Cihak, J.; Ziegler, H.W.; Koelsch, E., 1981: Regulation of immune responses against the syngeneic adj pc 5 plasma cytoma in balb c mice 1. analysis of immune parameters involved. The nonsecreting variant of ADJ-PC-5 plasma cell tumor of BALB/c mice is a highly malignant tumor, the LD50 being 30 cells/mouse after i.p. injection. Immunization against the tumor is possible. Four injections of 107 X-irradiated tumor cells at w...

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