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Regulation of immune responses against the syngeneic adj pc 5 plasma cytoma in balb c mice 3. induction of specific t suppressor cells to the balb c plasma cytoma adj pc 5 during early stages of tumorigenesis


, : Regulation of immune responses against the syngeneic adj pc 5 plasma cytoma in balb c mice 3. induction of specific t suppressor cells to the balb c plasma cytoma adj pc 5 during early stages of tumorigenesis. Immunology 47(3): 503-510

Initial stages of tumor growth are not easily accessible to investigation. An experimental procedure was developed to mimic tumorigenesis as closely as possible. BALB/c mice received i.p. exponentially increased numbers of irradiated syngeneic ADJ-PC-5 plasmacytoma cells. The initial injection began with 2 cells per mouse and, according to the generation time of this tumor, subsequent doses were doubled until mice had received up to 105 tumor cells. At various stages of treatment, peritoneal exudate cells (PEC) and spleen cells (SC) were tested for either cytotoxicity or specific suppression of induction of a primary in vitro T-cell cytotoxic response (CTL) of BALB/c spleen cells against ADJ-PC-5 plasmacytoma cells. No cytotoxic PEC were found. PEC from mice in which the final tumor cells number had reached or exceeded 103 irradiated ADJ-PC-5 cells, induced complete suppression of this primary in vitro CTL. Specificity was found both in the induction and effector phase of suppression. Specific suppression was mediated by Thy-1.2+ cells and amplified by nonspecific suppression through adherent cells. The data are discussed in context with findings on the in vivo immunogenicity and tolerogenicity of the ADJ-PC-5 plasmacytoma. Induction of T suppressor (Ts) cells might be an early event in tumorigenesis.

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Bannerman, P.G.; Shieh, A.; Oliver, T.; Pleasure, D.E., 1997: Glial growth factor-2 promotes the survival of mammalian neural crest cells. Society for Neuroscience Abstracts 23(1-2): 891

Horino, S., 1977: Environmental factors and work performance of foundry workers. Environmental factors such as atmospheric conditions, lighting, noise, and dust in foundry factories of different sizes were evaluated by direct physical measurements and a subjective rating method using an ergonomic checklist. Working postures an...

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Mahdy, R.A.; Nada, W.M.; Wageh, M.M.; Kader, M.A.; Saleh, M.M.; Alswad, M.M., 2011: Assessment safety and efficacy of a combination therapy of topical amphotericin B and subconjunctival fluconazole for the treatment of fungal keratitis. The study was aimed at evaluating the treatment of fungal keratitis using a combination therapy of a low concentration of topical amphotericin B (0.2 mg/mL) eye drops together with subconjunctival injections of 2 mg/mL of fluconazole. The study wa...

Wang, J.; Li, D.; Chen, N., 1996: Intracavitary microwave hyperthermia combined with external irradiation in the treatment of esophageal cancer. A randomized trial of intracavitary microwave hyperthermia combined with external irradiation (R+H) versus radiation (R) alone in the treatment of esophageal cancer was performed from Feb. 1986 to Feb. 1988. In the R group, radiation was given by...

Arrizabalaga, P.; Sole, M.; Iglesias, C.; Escaramis, G.; Ascaso, C., 2002: Renal expression of ICAM-1 and VCAM-1 in ANCA-associated vasculitis Are there differences between serologic groups?. Nephrology Dialysis Transplantation 17(Abstracts Supplement 1): 97

Svetlov P.G., 1967: Some laws governing ontogenesis and their relationship to the pre natal period of life. Review of Soviet Medical Sciences 4(1): 52-53

Cleary, C.S.; Power, M.J.; Schneider, S.; Webb, R.P.; Manning, R.J., 2011: Fast gain recovery rates with strong wavelength dependence in a non-linear SOA. We report remarkably fast and strongly wavelength-dependent gain recovery in a single SOA without the aid of an offset filter. Full gain recovery times as short as 9 ps were observed in pump-probe measurements when pumping to the blue wavelength s...

Sakai A., 1970: Temperature range producing injury due to extracellular freezing in plants. Low Temperature Science Series B Biological Sciences (28): 73-78

Hallfeldt, K.K.; Trupka, A.; Kalteis, T.; Stuetzle, H., 1999: Safe creation of pneumoperitoneum using an optical trocar. The blind insertion of the Veress needle and the first trocar may cause serious complications. Therefore, many surgeons perform a minilaparotomy to safely position the first trocar. However, especially in obese patients, the dissection may be diff...