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Regulation of immune responses against the syngeneic adj pc 5 plasma cytoma in balb c mice 3. induction of specific t suppressor cells to the balb c plasma cytoma adj pc 5 during early stages of tumorigenesis

, : Regulation of immune responses against the syngeneic adj pc 5 plasma cytoma in balb c mice 3. induction of specific t suppressor cells to the balb c plasma cytoma adj pc 5 during early stages of tumorigenesis. Immunology 47(3): 503-510

Initial stages of tumor growth are not easily accessible to investigation. An experimental procedure was developed to mimic tumorigenesis as closely as possible. BALB/c mice received i.p. exponentially increased numbers of irradiated syngeneic ADJ-PC-5 plasmacytoma cells. The initial injection began with 2 cells per mouse and, according to the generation time of this tumor, subsequent doses were doubled until mice had received up to 105 tumor cells. At various stages of treatment, peritoneal exudate cells (PEC) and spleen cells (SC) were tested for either cytotoxicity or specific suppression of induction of a primary in vitro T-cell cytotoxic response (CTL) of BALB/c spleen cells against ADJ-PC-5 plasmacytoma cells. No cytotoxic PEC were found. PEC from mice in which the final tumor cells number had reached or exceeded 103 irradiated ADJ-PC-5 cells, induced complete suppression of this primary in vitro CTL. Specificity was found both in the induction and effector phase of suppression. Specific suppression was mediated by Thy-1.2+ cells and amplified by nonspecific suppression through adherent cells. The data are discussed in context with findings on the in vivo immunogenicity and tolerogenicity of the ADJ-PC-5 plasmacytoma. Induction of T suppressor (Ts) cells might be an early event in tumorigenesis.

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