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Regulation of immune responses by i j gene products 2. presence of i j b and i j k suppressor factors in nonsuppressor x nonsuppressor f 1 mice

, : Regulation of immune responses by i j gene products 2. presence of i j b and i j k suppressor factors in nonsuppressor x nonsuppressor f 1 mice. Journal of Experimental Medicine 155(4): 955-967

Antigen-specific suppression to poly(Glu50-Tyr50) (GT) is under the control of 2 complementary immune suppressor (Is) genes located in the major histocompatibility (H-2) complex of the mouse. Suppressor strains of mice produce both suppressor T (Ts) cells and Ts-derived suppressor factors (TsF) that bear antigenic determinants of the I-J subregion of the H-2 complex. Nonsuppressor strains of mice are not suppressed by GT preimmunization. These nonsuppressor mice can be classified according to those that lack the ability to make GT-specific T cell-derived suppressor factor (GT-TsF) after GT injection (i.e., H-2a, I-Jk mice) and those that lack the ability to be suppressed by the appropriate GT-TsF (i.e., H-2b,g2, I-Jb mice). (H-2a .times. H-2b,g2)F1 hybrid mice apparently produce distinct GT-specific suppressor factors of both parental I-J haplotypes. Only the I-Jb-bearing GT-TsF derived from these F1 hybrid mice is able to induce 2nd-order suppressor cells (Ts2). This is consistent with the observation that injection of GT-TsF1 derived from C57BL/6 (I-Jb) mice into A/J (I-Jk) mice leads to the production of an antigen-specific I-Jk GT-TsF2. Is gene complementation thus occurs through a different cellular mechanism than was previously observed for Ir gene complementation. Complementing (nonsuppressor .times. nonsuppressor)F1 hybrid mice produce an I-Jb (and not an I-Jk) GT-TsF1 and an I-Jk (not an I-Jb) GT-TsF2, thus suggesting a heterogeneity of Ia loci within the I-J subregion. There apparently may be even more heterogeneity within the I-J subregion than was reported with regard to I-J expression on Ts.

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