EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of immune responses by i j gene products 3. poly glutamic acid 50 tyrosine 50 specific suppressor factor is composed of separate i j and idiotype bearing chains


Journal of Immunology 130(3): 1274-1279
Regulation of immune responses by i j gene products 3. poly glutamic acid 50 tyrosine 50 specific suppressor factor is composed of separate i j and idiotype bearing chains
Injection of poly(Gluk50Tyr50)(GT) into B10.BR (H-2k) mice induces GT-specific suppressor T cells and a T cell-derived suppressor factor (TsF1), which in turn induces a 2nd-order suppressor T cell (Ts2). B10.BR GT-TsF1 is composed of separate I-Jk and idiotype-bearing chains linked by disulfide bond(s). Functional suppressive activity requires both chains to be in association. Neither chain alone can induce Ts2, indicating that both chains must be seen in association and suggesting a single cellular target for the 2 chains. Experiments designed to interchange I-J-bearing chains of GT-TsF1 derived from different H-2 haplotypes indicate that only the homologous I-J and idiotype-bearing chains can reassociate into a suppressive moiety. These experiments may imply heterogeneity of I-J region gene products.


Accession: 006288656



Related references

Regulation of immune responses by I-J gene products. III. GT-specific suppressor factor is composed of separate I-J and idiotype-bearing chains. Journal of Immunology 130(3): 1274-1279, 1983

Functional characteristics of idiotype specific suppressor t cell factors that inhibit responses to poly l glutamic acid 60 l alanine 30 l tyrosine 10. Federation Proceedings 45(4): 1112, 1986

Immunoregulatory pathways in adult responder mice 3. establishment of a poly l glutamic acid 60 l alanine 30 l tyrosine 10 specific suppressor t cell clone from poly l glutamic acid 60 l alanine 30 l tyrosine 10 tolerant responders which afferently regulates delayed type hypersensitivity responses. JMCI (Journal of Molecular and Cellular Immunology) 2(1): 1-13, 1985

Mechanisms of genetic control of immune responses ii. nonresponsiveness in balb c poly l glutamic acid 50 l tyrosine 50 of specific cell mediated immune responses does not correlate with the absence of functional t cells or the induction of suppressor t cells. Immunogenetics 23(5): 292-301, 1986

Xid and normal mice express a light chain associated cross reactive idiotype in response to poly l tyrosine glutamic acid poly dl alanine poly l lysine and poly l tyrosine glutamic acid poly dl alanine poly l lysine methylated bovine serum albumin. Journal of Immunology 136(10): 3734-3743, 1986

Genetic control of t cell proliferative responses to poly glutamic acid 40 alanine 60 and poly glutamic acid 51 lysine 34 tyrosine 15 subregion specific inhibition of the responses with mono clonal ia antibodies. Immunogenetics 11(6): 617-628, 1980

Immune response to the p azo benzene arsonate poly l glutamic acid 60 l alanine 30 l tyrosine 10 conjugate 2. hapten specific t cells induced with p azo benzene arsonate poly l glutamic acid 60 l alanine 30 l tyrosine 10 in poly l glutamic acid 60 l alanine 30 l tyrosine 10 responder x nonresponder f 1 hybrids are restricted to the nonresponder haplotype. Journal of Immunology 130(2): 573-578, 1983

Lack of immune response gene control for induction of epitope specific suppression by the antigen poly l tyrosine l glutamic acid poly d l alanine poly l lysine. Nature (London) 295(5847): 329-331, 1982

Genetic control of major histo compatibility complex linked immune responses to synthetic poly peptides in man poly l phenylalanine l glutamic acid poly d l alanine poly l lysine and l glutamic acid l alanine l tyrosine 60 30 10/. Proceedings of the National Academy of Sciences of the United States of America 81(11): 3521-3525, 1984

Genetically controlled immune responses of inbred mouse strains to conjugates of the ordered peptides tyrosyltyrosylglutamyl glutamic acid and tyrosylglutamyltyrosyl glutamic acid with multi chain poly dl alanine as compared with the response to the random poly peptide containing tyrosine glutamic acid alanine and lysine. European Journal of Immunology 5(12): 866-871, 1975