+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of immune responses by i j gene products 4. distinct suppressor factors derived from nonsuppressor a strain mice

, : Regulation of immune responses by i j gene products 4. distinct suppressor factors derived from nonsuppressor a strain mice. Journal of Immunology 133(4): 1723-1729

A/J, A/WySn (H-2a, I-Jk), and B6 (H-2b, I-Jb) mice are poly(Glu50Tyr50)(GT) nonresponders. GT preimmunization does not suppress humoral immune responses to the immunogenic form of GT, GT-MBSA (GT-methylated bovine serum albumin), in these strains. B6 mice produce an idiotypic GT-specific T cell-derived suppressor factor (GT-TsF1) after GT injection, but cannot be suppressed by this or any other GT-TsF1. H-2a mice do not produce GT-TsF1, but can be suppressed by B6 GT-TsF1. Injection of cell-free B6 GT-TsF1 into H-2a mice leads to the production of 2 distinct I-Jk GT-TsF. These were designated GT-TsF2 and GT-TsF3 on the basis of their kinetic activity and antigenic markers. Anti-idiotypic I-Jk GT-TsF2 is suppressive at a time intermediate between GT-TsF1 and GT-TsF3. Idiotypic I-Jk GT-TsF3 suppresses GT-MBSA plaque-forming cell (PFC) responses the day of PFC assay. GT-TsF3, not GT-TsF1, suppresses B6 GT-MBSA PFC responses, indicating that these idiotypic factors are distinct. Thus, H-2a lack or have a defective Ts1 cell for GT suppression, and H-2b mice lack a functional Ts2 cell. These findings offer strategies for circumventing suppressor T cell defects in nonsuppressors.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006288657

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Willis E.O., 1982: The behavior of red billed woodcreepers hylexetastes perrotti. Red-billed woodcreepers (H. perrotti), which regularly follow army ants for flushed arthropods in forests from the Guianas south to central Brazil, were studied at Manaus, Brazil. They also forage away from ants, sometimes with forest flocks. Colo...

KRUMIN, K.A., 1956: Simplified plaster cast for congenital hip dislocation in infants. Ortopediia Travmatologiia i Protezirovanie 17(2): 45-46

Fei, G.; Wittmann, S.; Richon, V.; Bhalla, K., 2002: Co-Treatment with the Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Enhances Apo-2L/TRAIL-Induced Death Inducing Signaling Complex and Apoptosis of Human Acute Lymphoid Leukemia Cells. SAHA (Suberoylanilide hydroxamic acid) is a known inhibitor of histone deacetylases (HDACs), which catalyze deacetylation of amino terminal lysine residues of the core nucleosomal histones, an activity implicated in chromatin remodeling and the tr...

Fried M.; Erlacher U.; Koerfer J.; Beglinger C.; Stalder G., 1990: Role of cck in the regulation of gastric emptying pancreatic secretion and insulin release in man. Digestion 46(SUPPL 1): 33-34

Herndon, B.; Dall, L.; Suvarna, P., 1995: Contribution of the host to test results in assays of Staphylococcus epidermidis. From two human populations (one pediatric and one adult), clinically diagnosed with Staphylococcus epidermidis (S. epidermidis) sepsis of similar severity, bacteria were isolated from pre-antibiotic blood samples and evaluated for virulence. The L...

Outerelo, R., 1983: Mayetia (s. str.) cantabrica n. sp. de Santader (Espana). Septima nota sobre el genero Mayetia Mulsant & Rey de la peninsula iberica. (Col., Pselaphidae). Eos Revista Espanola de Entomologia1983]; 58: 217-221

Oakley-Girvan, I.; Feldman, D.; Eccleshall, T.Ross.; Gallagher, R.P.; Wu, A.H.; Kolonel, L.N.; Halpern, J.; Balise, R.R.; West, D.W.; Paffenbarger, R.S.; Whittemore, A.S., 2004: Risk of early-onset prostate cancer in relation to germ line polymorphisms of the vitamin D receptor. Vitamin D inhibits prostate cancer cell growth, angiogenesis, and metastasis. These actions are mediated by the vitamin D receptor. We examined associations between prostate cancer risk and five polymorphisms in the VDR gene: four single nucleotid...

Yamada, H.; Katoh, A.; Ishinaga, H., 2003: A case of bilateral cervical lymph node metastasis of thyroglossal duct cancer. We reported a case of thyroglossal duct cancer, which metastasized to the bilateral cervical lymph nodes. The cervical lymph node metastases were detected in the upper portion of the neck. According to the results obtained in the preoperative fine...

KARTSEVA, A.G., 1964: Characteristics Of Changes In Peripheral Circulation After Ligation Of The Abdominal Aorta. Fiziolohichnyi Zhurnal 10: 601-608

Barontna, L.A.; Tsilyurik, I.T., 1967: Blood coagulation system and vascular resistance in patients with uterine cancer during radiation therapy. The following were observed in 130patients: recalcification time, amounts of proaccelerin, proconvertin and pro-thrombin, prothrombin consumption, blood clot retraction index, free blood heparin, thrombin time and also skin capillaries resistance....