EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of immune responses part 2 the cellular basis of cyclic amp effects on humoral immunity


Cellular Immunology 24(2): 220-229
Regulation of immune responses part 2 the cellular basis of cyclic amp effects on humoral immunity
DbcAMP [dibutyryl cyclic AMP], when added at 10-3 M for the first 12 h, can increase the number of AFC [antibody-forming cells] to SRBC [sheep red blood cells] (a TD [thymus-dependent] antigen) and POL [Salmonella adelaide polymerized flagellin] (a TI [thymus-independent] antigen) in antigen-stimulated CBA/J [mouse] spleen cell cultures. The cellular basis of DbcAMP action was investigated. DbcAMP does not act by a direct B [bone marrow-derived] cell effect. It does not stimulate the activity of T [thymus-derived] helper cells, and it inhibits the function of macrophages. The stimulatory activity of DbcAMP to anti-SRBC and anti-POL responses is through inhibition of a .theta.-bearing regulator (or suppressor) cell. Removal of T cells by anti-.theta. treatment has the same effect on the anti-POL response as treatment with DbcAMP. In the absence of T cells, the enhanced anti-POL response was insensitive of DbcAMP treatment. The number of anti-SRBC AFC formed is probably regulated by the ratio of T helper to T regulator cells.


Accession: 006288663



Related references

Regulation of immune responses. II. The cellular basis of cyclic AMP effects on humoral immunity. Cellular Immunology 24(2): 220-229, 1976

Effects of anti-schistosomal chemotherapy on immune responses, protection and immunity. I. Changes in cellular and humoral responses. American Journal of Tropical Medicine and Hygiene 35(1): 100-109, 1986

Local immunity in the pig respiratory tract part 1 cellular and humoral immune responses following swine influenza infection. Annales de Microbiologie (Paris) 128B(1): 95-108, 1977

Regulation of immune responses part 1 effects of cyclic amp and cyclic gmp on immune induction. Cellular Immunology 24(2): 209-219, 1976

Regulation of the immune response by subclasses of thymus derived lymphocytes part 2 the effect of adult thymectomy upon humoral and cellular responses in mice. European Journal of Immunology 5(5): 337-343, 1975

Immune activities in SAM mice Cellular and genetic basis for the impaired responsiveness of helper T cells in the humoral immunity. Takeda, T International Congress Series; The SAM model of senescence 41-46, 1994

Early nutritional experiments: effects on the humoral and cellular immune responses in mice Obesity, protein-energy deficiency, immune responses. Journal of nutrition 113(6): 1131-1139, 1983

Hormonal regulation of the immune response. II. The effect of thyroidectomy in rats on humoral and cellular immunity. Eksperimentalna Meditsina i Morfologiia 25(3): 7-11, 1986

Local immunity in the pig respiratory tract. I. -- Cellular and humoral immune responses following swine influenza infection. Annales de Microbiologie 128b(1): 95-107, 1977

Regulation of cellular and humoral immune responses by T-cell subclasses. Cold Spring Harbor Symposia on Quantitative Biology 41 Pt 1: 23-32, 1977