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Regulation of immune responses part 2 the cellular basis of cyclic amp effects on humoral immunity

, : Regulation of immune responses part 2 the cellular basis of cyclic amp effects on humoral immunity. Cellular Immunology 24(2): 220-229

DbcAMP [dibutyryl cyclic AMP], when added at 10-3 M for the first 12 h, can increase the number of AFC [antibody-forming cells] to SRBC [sheep red blood cells] (a TD [thymus-dependent] antigen) and POL [Salmonella adelaide polymerized flagellin] (a TI [thymus-independent] antigen) in antigen-stimulated CBA/J [mouse] spleen cell cultures. The cellular basis of DbcAMP action was investigated. DbcAMP does not act by a direct B [bone marrow-derived] cell effect. It does not stimulate the activity of T [thymus-derived] helper cells, and it inhibits the function of macrophages. The stimulatory activity of DbcAMP to anti-SRBC and anti-POL responses is through inhibition of a .theta.-bearing regulator (or suppressor) cell. Removal of T cells by anti-.theta. treatment has the same effect on the anti-POL response as treatment with DbcAMP. In the absence of T cells, the enhanced anti-POL response was insensitive of DbcAMP treatment. The number of anti-SRBC AFC formed is probably regulated by the ratio of T helper to T regulator cells.

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