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Regulation of immune responses via genetically restricted cellular interactions 1. augmentation of antibody responses by idiotype specific enhancing b lymphocytes

, : Regulation of immune responses via genetically restricted cellular interactions 1. augmentation of antibody responses by idiotype specific enhancing b lymphocytes. Journal of Immunology 133(6): 2882-2887

B lymphocytes obtained from BALB/c mice that had been immunized with M104E myeloma protein have an idiotype-specific enhancing activity for anti-dextran B1355S antibody responses in vivo. The enhancing cells were Thy-1-, Lyt-1-,2-, nylon wool-adherent and rabbit anti-mouse Ig (RAMG) dish adherent. The in vitro analysis described in this report also revealed that the enhancing cells had a B cell phenotype and were specifically enriched in M104E or J558 myeloma protein-coated dishes but not by irrelevant monoclonal antibodies. The significance of these B-B cell interactions were analyzed in vitro by using various Igh-1 and H-2 congeneic strains of mice. The idiotype immune B lymphocytes obtained from BALB/c and BAB-14 could enhance the anti-dextran antibody responses of BALB/c B lymphocytes in an idiotype-specific manner. C.AL-20 and CB-20 strains could not induce the idiotype-specific enhancing B cell activity in dextran-immune BALB/c B cells. The capability of enhancing B cell induction is probably related to the producibility of the respective idiotype in that strain of mice. The B cells obtained from BALB/c mice immune to the idiotype cooperated well with the dextran-immune B cells of BALB/c but not BALB.K and vice versa. Successful cooperation between those 2 types of B lymphocytes apparently requires the same MHC[major histocompatibility complex] haplotype. The roles of these genetically restricted cellular interactions in the immune system are discussed.

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