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Regulation of immuno globulin m and immuno globulin d synthesis in b lymphocytes 2. translational and post translational events


, : Regulation of immuno globulin m and immuno globulin d synthesis in b lymphocytes 2. translational and post translational events. Journal of Immunology 132(3): 1566-1570

Studies investigating the relative rates of biosynthesis of .mu.- and .delta.-polypeptide chains in normal resting [mouse] B lymphocytes have shown that the translation rate of .mu.m is about 7-fold higher than that of .delta.m, thus reflecting the relative abundance of mRNA encoding these 2 chains. The turnover rate of cell surface IgM is faster than that of cell surface IgD, resulting in higher expression of cell surface IgD relative to IgM under steady-state conditions. LPS [lipopolysaccharide] stimulation of B lymphocytes induces the complete cessation of synthesis of the .delta.-chain, thus accounting for the gradual dissappearance of IgD from the cell surface of activated cells.

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