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Regulation of immunoglobulin g 1 and immunoglobulin g 2 subclass expression by adjuvant activated splenic suppressor t cells

, : Regulation of immunoglobulin g 1 and immunoglobulin g 2 subclass expression by adjuvant activated splenic suppressor t cells. Cellular Immunology 91(2): 467-476

Spleen cells from mice immunized with different adjuvants are able to suppress secondary in vitro IgG plaque-forming cell (PFC) responses. The suppressive effect is mediated by Lyt-2-positive T cells. IgG subclasses are affected differentially depending on the number of T suppressor (Ts) cells added in the assays. At low Ts cell concentration IgG2a and IgG2b PFC responses are selectively inhibited. At higher Ts cell concentration IgG1 responses could also be completely inhibited, but IgA and IgM responses are not affected. Suppressor cells responsible for IgG1, IgG2a and IgG2b suppression are never found in the draining lymph nodes of adjuvant-immunized animals.

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