+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of immunoglobulin g memory responses by helper and suppressor t cells activated by the type 2 antigen polyvinylpyrrolidone

, : Regulation of immunoglobulin g memory responses by helper and suppressor t cells activated by the type 2 antigen polyvinylpyrrolidone. Journal of Experimental Medicine 161(6): 1357-1367

T cells from CAF1 mice immunized with various amounts of the type 2 antigen polyvinylpyrrolidone (PVP) were assessed for their ability to provide help to PVP-specific memory B cells for the production of IgG. Low doses (0.0025 .mu.g) of PVP consistently activated helper T cells (Th), which were required for the production of IgG by primed B cells. T cells from mice primed with higher amounts (0.25 or 25 .mu.g) of PVP did not provide significant help to the same B cells for IgG production. When mixed with B cells and low-dose PVP-primed Th, T cells from mice primed with 0.25 or 25 .mu.g PVP suppressed PVP-specific IgG, but not IgM antibody responses. The suppressor cells induced by higher amounts of PVP were eliminated either by injecting cyclophosphamide (CY) before priming with PVP, or by treating the primed T cells with anti-Lyt-2.2 and complement before transfer. Pretreatment of suppressor T cell (Ts) donors with CY or removal of Lyt-2+ T cells not only eliminated Ts activity, but also unmasked significant Th activity in the T cells from high-dose PVP-primed mice. Thus, both low and high amounts of PVP can activate Th, although high amounts of PVP also induce Ts, the activity of which predominates in a normal unfractionated T cell population. The amount of PVP (0.0025 .mu.g) that induces dominant help for IgG memory responses was only marginally immunogenic for induction of primary PVP-specific IgM responses, while 0.25 and 25 .mu.g PVP, which induce dominant suppression for IgG memory responses, are optimally immunogenic for primary IgM responses. These results are discussed in the context of the inability of most type 2 antigens to elicit primary IgG responses or to prime memory B cells for production of IgG, responses which are dependent on the function of antigen-specific Th.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006288690

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Bleul, U., 2003: False pregnancy in goats and sheep. False pregnancy occurs more frequently in goats than in sheep, and is due to hormone balance disorders which result in fluid accumulation in the uterus. It can occur in 3-20% of animals in goat flocks, and is more frequent in older than in younger...

Nakasone J., 1986: Vasodilating effects of nicorandil and nitroglycerin in anesthetized open chest dogs. Vasodilating effects of intravenous administrations of nicorandil (SG-75) and nitroglycerine were analyzed in anaesthetized open-chest dogs by measuring simultaneously, and continuously, coronary (CBF), vertebral (VBF), renal (RBF) and aortic bloo...

Jensen R.G.; Gordon D.T.; Scholfield C.R., 1973: Hydrolysis of linoleate geometric isomers by geotrichum candidum lipase. Lipids 8(5): 323-325

Lechi A., 1985: Kinetics of bumetanide sensitive sodium potassium co transport in erythrocytes of essential hypertensive patients. 1. Outward bumetanide-sensitive Na+-K+ cotransport was studied in the erythrocytes of 51 subjects, 24 normotensive subjects and 27 hypertensive patients, matched for sex and age. 2. Three kinetic parameters of this cation transport system were con...

Kaminskiy F. V.; Klyuyev Yu A.; Konstantinovskiy A. A.; Piotrovskiy S. V.; Sochneva E. G.; Yuzhakov V. M., 1975: Indicators of diamond occurrence in alkali basaltoids of the northern Russian Platform. Doklady Akademii Nauk SSSR 222(4): 939-941

Weise, E.; Wormuth, H. J.; Schutt Abraham, I.; Levetzow, R., 1987: High voltage stunning of chickens and its effect on meat quality. Previous laboratory experiments indicated that an adequate stunning effect in line with animal welfare requirements could only be guaranteed by simultaneous occurrence of heart fibrillation. In this study it was shown under practical conditions in...

Lee, F. A.; Gortner, W. A.; Whitcombe, J., 1946: Effect of freezing rate on vegetables. Appearance, palatability, and vitamin content of peas and snap beans. Five rates of freezing, very rapid, very slow, and intermediate, were shown to effect no significant differences in vitamin content and palatability of peas and snap beans after freezing, after storage (6 months at -6 degrees C.), or after cooking...

Lofts, B.; Massa, R., 1980: Male reproduction. This review includes consideration of androgen secretion, testosterone metabolism, steroidogenesis, and gonadotropin secretion and testicular feedback relationships, with some reference to poultry.

Hooker, L. W., 1951: Logging damage: tree-length skidding vs. log-length skidding. Preliminary results of a study of the effect of arch skidding of tree-length logs, indicated that although this method injured more trees per skidding turn, ground skidding of shorter logs produced 42% more damage per 1, 000 ft. of logs skidded. T...

Gabe M.; Martoja M., 1969: Contribution to the histology of the endocrine pancreas of eliomys quercinus. Archivum Histologicum Japonicum 30(2): 123-147