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Regulation of immunoglobulin synthesis by lymphocytes in multiple myeloma and benign monoclonal gammopathy


Nihon Ketsueki Gakkai Zasshi 49(6): 1195-1205
Regulation of immunoglobulin synthesis by lymphocytes in multiple myeloma and benign monoclonal gammopathy
The distribution and regulatory function of lymphocyte subsets on immunoglobulin synthesis were assessed using several monoclonal antibodies in samples from 13 patients with multiple myeloma (MM) and 9 patients with benign monoclonal gammopathy (BMG). Since all of these cells were separated directly with a cell sorter, their purity and viability were extremely good. A reduction of lymphocytes was observed in MM. The proportion and absolute number of OKT4 positive cells were significantly reduced, and the proportion of OKT8 positive cells was increased in MM when compared with normal controls. The OKT4/OKT8 ratio was reduced in MM. The helper function of OKT4 positive cells of MM on pokeweed mitogen-stimulated immunoglobulin synthesis was reduced when compared with normal controls, but the suppressor function of OKT8 positive cells of MM on immunoglobulin synthesis was within normal limits. None of these abnormalities were observed in BMG.


Accession: 006288698

PMID: 3492847



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