EurekaMag.com logo
+ Translate

Regulation of immunoglobulin synthesis by monocytes in multiple myeloma and benign monoclonal gammopathy


, : Regulation of immunoglobulin synthesis by monocytes in multiple myeloma and benign monoclonal gammopathy. Clinical and Experimental Immunology 66(3): 625-632

The distribution and regulatory function of immunoglobulin (Ig) synthesis by monocytes were assessed using several monoclonal antibodies and a cell sorter in samples from 13 patients with multiple myeloma (MM) and nine patients with benign monoclonal gammopathy (BMG). Since all of these cells were separated directly with the cell sorter, their purity and viability were greater than 98% and greater than 99%, respectively. The absolute number of lymphocytes was significantly reduced. The number of monocytes stained with non-specific esterase was within normal range in MM and BMG, as were the absolute number and the proportion of cells which reacted with OKM1 and Mo2 (OKM1+ cells and Mo2+ cells, respectively). The helper activity of monocytes in Ig synthesis stimulated with pokeweed mitogen (PWM) was impaired in MM compared with normal controls. None of these abnormalities in the distribution and regulatory function of monocytes was observed in BMG. The possible immunoregulatory mechanism of MM is discussed.

(PDF 0-2 workdays service)

Accession: 006288699

PMID: 3568450

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Takeshita, A., 1986: Regulation of immunoglobulin synthesis by lymphocytes in multiple myeloma and benign monoclonal gammopathy. The distribution and regulatory function of lymphocyte subsets on immunoglobulin synthesis were assessed using several monoclonal antibodies in samples from 13 patients with multiple myeloma (MM) and 9 patients with benign monoclonal gammopathy (B...

Peest, D.; Brunkhorst, U.; Schedel, I.; Deicher, H., 1984: In vitro immunoglobulin production by peripheral blood mononuclear cells from multiple myeloma patients and patients with benign monoclonal gammopathy. Regulation by cell subsets. Peripheral blood mononuclear cells (PBM) from four patients with IgG myeloma and four patients with benign monoclonal gammopathy (BMG) were stimulated with pokeweed mitogen (PWM), and the in vitro immunoglobulin production over 7 days was measured...

Suzuki, K.; Hirokawa, K.; Hatakeyama, S., 1984: Age-related change of distribution of immunoglobulin containing cells in human bone marrow. Changes in patients with benign monoclonal gammopathy and multiple myeloma. The number and mode of distribution of immunoglobulin containing cells in human bone marrow were investigated immunohistochemically using paraffin sections of bone marrow aspirates. In individuals without specific diseases, the number of immunoglo...

Okagawa K.; Iguchi K.; IIshi Y.; Kosaka M., 1985: Subsets of t cells in myeloma macroglobulinemia and benign monoclonal gammopathy analysis of surface markers defined by monoclonal antibodies and effect on immunoglobulin synthesis by b cells. The surface markers and function of peripheral T cells were analyzed in 34 patrients with IgG- or IgA-myeloma, 3 with BJP-myeloma, 5 with macroglobulinemia and 16 with benign monoclonal gammopathy (BMG) to elucidate the effects of monoclonal B cel...

Watanabe, T.; Suzuki, H.; Unakami, H., 1988: IgG-K benign monoclonal gammopathy, IgG-K multiple myeloma and Bence Jones-L multiple myeloma in three brothers. Rinsho Byori. Japanese Journal of Clinical Pathology 36(2): 233-236

Shimizu, K.; Ohnishi, K.; Kunii, A., 1982: Differentiation of benign monoclonal gammopathy and smouldering multiple myeloma from frank myeloma. Circulating immunoglobulin (Ig) secreting cells of each type of the different Ig classes were enumerated using a reverse haemolytic plaque assay in nine subjects with the pre-clinical phase of IgG myeloma (six with benign monoclonal gammopathy and...

Pettersson, D.; Mellstedt, H.; Holm, G.; Bjorkholm, M., 1981: Monoclonal blood lymphocytes in benign monoclonal gammopathy and multiple myeloma in relation to clinical stage. 20 patients with benign monoclonal gammopathy (BMG) have been studied for blood lymphocyte and subpopulations. 4 patients had slightly decreased T-lymphocyte values. Total B-lymphocytes were within the normal range. In 3 BMG patients an abnormal r...

Van Camp, B.; Coomans, D.; Massart, D.L.; D.W.ele, M.; Thielemans, C., 1982: Discriminant analysis of parameters referring to the monoclonal cellular event in multiple myeloma and benign monoclonal gammopathy. Acta Clinica Belgica 37(6): 348-355

Pusterla, N.; Stacy, B.A.; Vernau, W.; D.C.ck, H.E.V.; Magdesian, K.G., 2004: Immunoglobulin A monoclonal gammopathy in two horses with multiple myeloma. The clinical findings in two horses with secretory multiple myeloma and secondary immunoglobulin A (IgA) monoclonal gammopathy were nonspecific and included weight loss, pale mucous membranes, limb oedema and bacterial respiratory tract infection...

Paglieroni, T.; MacKenzie, M.R., 1979: In vitro cytotoxic response to human myeloma plasma cells by peripheral blood leukocytes from patients with multiple myeloma and benign monoclonal gammopathy. Peripheral blood leukocytes (PBL) from myeloma patients were studied for their capacity to lyse plasma cells from myeloma patients, benign monoclonal gammopathy (BMG) patients, and nonneoplastic disease patients. Plasma cells were isolated from bo...