+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of immunoglobulin transcription rates and messenger rna processing in proliferating normal b lymphocytes by activators of protein kinase c

, : Regulation of immunoglobulin transcription rates and messenger rna processing in proliferating normal b lymphocytes by activators of protein kinase c. Proceedings of the National Academy of Sciences of the United States of America 84(24): 9135-9139

Immunoglobulin gene expression in normal splenic B lymphocytes stimulated with lipopolysaccharide was selectively down-regulated by anti-IgM antibodies and a protein-kinase C-activating phorbol ester, phorbol 12,13-dibutyrate. This control was concomitant with a decreased rate of transcription of the IgM gene while "polymerase pausing" was induced in the IgD gene. The suppression was resistant to treatment with cycloheximide, indicating that it was not caused by a labile repressor protein. The down-regulation of immunoglobulin gene expression affected only the secretory form of immunoglobulin, while the mRNA levels for the membrane-bound form of immunoglobulin remained unaltered. We conclude that the mechanisms controlling immunoglobulin gene expression in untransformed B lymphocytes differ from those operating in tumors derived from the same cell lineage.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006288700

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Pavlik, Valory N.; Hyman, David J.; Festa, Nicolo A.; Dyer, Carmel Bitondo, 2001: Quantifying the problem of abuse and neglect in adults: Analysis of a statewide database. BACKGROUND: Mistreatment of adults, including abuse, neglect, and exploitation, affects more than 1.8 million older Americans. Presently, there is a lack of precise estimates of the magnitude of the problem and the variability in risk for differen...

Slavskaya A. I.; Bogoslovskaya Ye I.; Kukoyev V. A.; Rudnichenko V. Ye; Samokhvalova L. G., 1976: Reaction of nickel orthosilicate with pyrrhotite upon heating. Transactions (Doklady) of the US

Edwards, Louise; Slassi, Abdelmalik; Tehim, Ashok; Xin, Tao, 2001: Azaindoles having serotonin receptor affinity. Described herein are compounds with affinity for the 5-HT6 receptor, which have the general formula I: ##STR1## wherein: R represents a group of Formula II or Formula III; one of A, B D or E is a N atom, the remainder being CH groups; R1 is select...

Hay, Elizabeth D., 1959: Electron microscopic observations of muscle dedifferentiation in regenerating Amblystoma limbs. The changes in the fine structure of skeletal muscle fibers of the amphibian limb as they dedifferentiate to form mononucleate blastema cells are described. In the 2 to 6 day period after amputation of the limb, all differentiated stump tissues de...

Jorrin J.; Lopez Valbuena R.; Tena M., 1990: Effects of actinomycin d cordycepin and cycloheximide on phenylalanine ammonia lyase turnover in sunflower hypocotyls. Light/sucrose treatment of sunflower [Helianthus annuus] hypocotyls originated cyclic changes of PAL activity with alternative periods of increase and decrease of activity and maxima at 4 and 28 h (Tena et al., 1984). Actinomycin D, cordycepin and...

Huang Qi; Jiang ZhiWei; Jiang Jun; Li Ning; Li JieShou, 2004: Chylous ascites: treated with total parenteral nutrition and somatostatin. AIM: To determine the effects of total parenteral nutrition and somatostatin on patients with chylous ascites. METHODS: Five patients were diagnosed with chylous ascites on the basis of laboratory findings of ascites sample from November 1999 to M...

Singh, S. P.; Choudhary, S. K., 1999: Effect of some insecticides on shoot and fruit borer (Earias vittella Fabricius) incidence on okra plant (Abelmoschus esculentus). Studies carried out in India showed that out of 6 insecticides applied against Earias vittella in okras, endosulfan resulted in the greatest yields, however, the greatest cost:benefit ratios were obtained with cypermethrin and fenvalerate.

Shono M.; Ezoe K.; Kaniwa M A.; Ikarashi Y.; Kojima S.; Nakamura A., 1991: Allergic contact dermatitis from para tertiary butylphenol formaldehyde resin ptbp fr in athletic tape and leather adhesive. 4 girls with severe allergic contact dermatitis from a brand of athletic tape and a cobbler with allergic contact dermatitis from leather adhesive are presented. Alkylphenol resin with unknown chemical structure had been compounded in both product...

Shearman Douglas J., 1970: Evaporite-carbonate relations in basin development. The American Association of Petroleum Geologists Bulletin 54(5): 870

Waterfield, C. J.; Timbrell, J. A., 1996: The biosynthesis of taurine from N-acetyl-L-cysteine and other precursors in vivo and in rat hepatocytes. The synthesis of taurine from N-acetylcysteine has been examined in rats in vivo and in rat hepatocyte suspensions in vitro. In rats in vivo, administration of N-acetylcysteine significantly increased urinary taurine (3 fold) 24h after dosing and...