+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of in vitro cyto toxic t lymphocyte generation 1. evidence that killer cell precursors differentiate to effector cells in 2 steps

, : Regulation of in vitro cyto toxic t lymphocyte generation 1. evidence that killer cell precursors differentiate to effector cells in 2 steps. Journal of Experimental Medicine 155(3): 783-796

The differentiation of mouse cytotoxic T lymphocyte precursor cells (CTL-P) into CTL effector cells is a 2-step process. In the 1st step, naive CTL-P (CTL-PN) become activated (CTL-PA) but do not yet have the capacity to kill target cells. CTL-PA can be distinguished from CTL-PN because the former are far less sensitive than the latter to the effects of in vitro-generated suppressor cells. Thus, the addition of suppressor T cells (Ts) to a fresh mixed leukocyte culture (MLC) can totally inhibit the production of CTL from CTL-PN; the same Ts only minimally affect the generation of CTL from CTL-PA. It is not known whether these Ts act directly on CTL-PN or on a helper cell needed for activation to CTL-PA. The production of CTL-PA can take place in allogeneic MLC treated with the drug pyrilamine or when heat-inactivated stimulator cells are used. Each of these treatments inhibits the differentiation of CTL-PA to CTL. However, if pyrilamine is removed, a nonspecific. MLC-derived signal can induce these CTL-PA to become CTL, even in the presence of significant numbers of Ts. This 2 step process of differentiation of CTL-P to CTL may be analogous to the way naive B cells become antibody-producing cells.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006288704

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Kasper, J., 1982: Effect of white clover and mineral fertilizer nitrogen on the productivity of mixed feeds containing grasses. Pol'nohospodarstvo = Agriculture8(8): 688-696

Lin, C-Hsien.; Chung, C-Ang.; Wong, J-Hong.; Chen, B-Kuen.; Chiu, S-Jin.; Klahan, S.; Lee, Y-Chao.; Chang, W-Chiao., 2016: Involvement of L-type Ca²⁺ channel and toll-like receptor-4 in nickel-induced interleukin-8 gene expression. The metal nickel (Ni(2+)) is found everywhere in our daily lives, including coins, costume jewelry, and even nuts and chocolates. Nickel poisoning can cause inflammatory reactions, respiratory diseases, and allergic contact dermatitis. To clarify...

Adams, D.; Clark, R.; Reece, P.; Volesky, J., 1998: Research and education for managing resources within the Nebraska Sandhills: the Gudmundsen Sandhills Laboratory. Rangelands 20(5): 4-8

Batey, T.; Reynish, D.J., 1976: The influence of nitrogen fertilizer on grain quality in winter wheat. In 44 trials in 1966-9 winter wheat was given 5 rates of N in the range 0-175 kg/ha as ammonium nitrate applied in spring. In almost all trials increasing the rate of applied N decreased grain size and increased grain N content. The year with the...

Cardinale, A.E.; Pauli, W., 2001: Science hall of fame. Wolfgang Pauli, in the centenary of his birth. La Radiologia Medica 100(3): 99-103

Docherty, J.R., 2014: Prazosin has low potency at α1A-adrenoceptors and high potency at α1D -adrenoceptors in rat vas deferens. (1) We have investigated α1 -adrenoceptor subtypes mediating contractions to noradrenaline in epididymal portions of rat vas deferens. (2) Contractions to noradrenaline were investigated in the absence or presence of the noradrenaline transporter...

Anonymous, 2013: How to discontinue steroid medication. Mmw Fortschritte der Medizin 155(12): 20-20

Rolón, M.; Vega, Mía.Celeste.; Román, F.; Gómez, A.; Rojas de Arias, A., 2011: First report of colonies of sylvatic Triatoma infestans (Hemiptera: Reduviidae) in the Paraguayan Chaco, using a trained dog. In the Gran Chaco region, control of Triatoma infestans has been limited by persistent domestic infestations despite the efforts of the Vector Control Services. In Paraguay, this region is the highest endemic area in the country, showing high leve...

Sevinc, S.; Ors Kaya, S.; Akcam, T.Ilker.; Ceylan, K.Can.; Ozturk, O.; Susam, S., 2015: Prolonged Air Leakage in Secondary Spontaneous Pneumothorax: Is Proportion of Emphysema Important?. Prolonged air leakage is the most common complication that can cause severe problems in cases of secondary spontaneous pneumothorax (SSP). The purpose of this study was to explore whether Goddard Classification Score (GCS) can be a marker of prolo...

Reisman, H.B., 1964: Italy: Science and Politics. Science 145(3639): 1387-1387