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Regulation of in vitro cyto toxic t lymphocyte generation 2. demonstration of noncytotoxic allo antigen specific suppressor t lymphocytes

, : Regulation of in vitro cyto toxic t lymphocyte generation 2. demonstration of noncytotoxic allo antigen specific suppressor t lymphocytes. European Journal of Immunology 12(5): 380-386

Both allospecific suppressor T lymphocytes (TSS) and nonspecific suppressor T lymphocytes (TSN) are activated in alloantigen-stimulated mouse mixed leukocyte cultures (MLC). TSS and TSN can suppress cytotoxic T lymphocyte (CTL) induction upon transfer to fresh (2nd) MLC stimulated by the same alloantigens as in the 1st MLC (TSS or TSN) or by 3rd-party alloantigens (TSN only). Evidence tht TSS and TSN functions are performed by different T cell sets has been restricted to radioresistance of the former but not the latter. Separation of TSS from CTL has proven even more difficult. Methods are reported here which have allowed in vitro induction and functional separation of TSS from CTL and TSN in a totally allogeneic system. TSS are resistant to combined exposure to pyrilamine, a histamine1 antagonist and local anesthetic, during suppressor cell induction, and to X or .gamma. irradiation thereafter, while CTL precursors (CTL-P) and TSN are more sensitive to such treatments. These treatments were used to generate TSS that are not contaminated with functional CTL, CTL-P or TSN. Thus, TSS regulate CTL induction by interacting with responding cell populations, rather than by cytotoxic depletion of stimulator cells.

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