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Regulation of in vitro generation of cell mediated cyto toxicity 2. characterization of thymosin induced suppressor t cells

Immunopharmacology 2(4): 301-312
Regulation of in vitro generation of cell mediated cyto toxicity 2. characterization of thymosin induced suppressor t cells
Thymosin fraction 5 can induce the appearance of [mouse] suppressor T cells capable of regulating the in vitro generation of cytotoxic T lymphocytes (CTL) in a 5 day allogeneic or syngeneic mixed lymphocyte-tumor culture (MLTC). Characterization of the syppressor cell population demonstrated it to be a nonadherent, cyclophosphamide-sensitive T cell. Adult thymectomy (Tx) eliminated suppressor cell precursors in spleen, pointing to a direct thymic dependence of the population. Kinetic studies showed that the thymosin influence was necessary for at least the first 12 h of culture for optimal suppression to occur. The in vitro-generated suppressor T cells were antigen specific and could be generated with spleen, thymus or lymph node cell preparations, suggesting the widespread existence of a regulatory T cell population under direct humoral thymic control.

Accession: 006288709

PMID: 6450736

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