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Regulation of in vitro generation of cell mediated cyto toxicity 2. characterization of thymosin induced suppressor t cells


, : Regulation of in vitro generation of cell mediated cyto toxicity 2. characterization of thymosin induced suppressor t cells. Immunopharmacology 2(4): 301-312

Thymosin fraction 5 can induce the appearance of [mouse] suppressor T cells capable of regulating the in vitro generation of cytotoxic T lymphocytes (CTL) in a 5 day allogeneic or syngeneic mixed lymphocyte-tumor culture (MLTC). Characterization of the syppressor cell population demonstrated it to be a nonadherent, cyclophosphamide-sensitive T cell. Adult thymectomy (Tx) eliminated suppressor cell precursors in spleen, pointing to a direct thymic dependence of the population. Kinetic studies showed that the thymosin influence was necessary for at least the first 12 h of culture for optimal suppression to occur. The in vitro-generated suppressor T cells were antigen specific and could be generated with spleen, thymus or lymph node cell preparations, suggesting the widespread existence of a regulatory T cell population under direct humoral thymic control.

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Accession: 006288709

PMID: 6450736

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Related references

Marshall, G.D.; Thurman, G.B.; Goldstein, A.L., 1980: Regulation of in vitro generation of cell-mediated cytotoxicity. II. Characterization of thymosin-induced suppressor T cells. Thymosin fraction 5 can induce the appearance of suppressor T cells capable of regulating the in vitro generation of cytotoxic T lymphocytes (CTL) in a 5-day allogeneic or syngeneic mixed lymphocyte-tumor culture (MLTC). Characterization of the su...

Marshall, G.D.; Thurman, G.B.; Goldstein, A.L., 1980: Regulation of in vitro generation of cell-mediated cytotoxicity. In vitro induction of suppressor T lymphocytes by thymosin. Journal of the Reticuloendothelial Society 28(2): 141-149

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