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Regulation of in vitro human leukocyte interferon production effects of prostaglandin synthetase and phosphodiesterase inhibition

, : Regulation of in vitro human leukocyte interferon production effects of prostaglandin synthetase and phosphodiesterase inhibition. Research Communications in Chemical Pathology & Pharmacology 54(3): 379-394

A great variability exists in the in vitro capability of peripheral blood leukocyes (PBL) of apparently healthy adults to produce IFN-.alpha. In this report, we have studied the effects of prostaglandins, indomethacin and pentoxifylline upon IFN-.alpha. production by the PBL of normal healthy donors. The donors were divided into two groups: "normal producers".sbd.donors that consistently produced > 2,000 ref. units IFN-.alpha. per 107 PBL and "low producers".sbd.donors that consistently produced < 2,000 ref. units IFN-.alpha. per 107 PBL. Addition of exogenous PGE1 or PGE2 into interferon production media significantly inhibited IFN-.alpha. yield by the PBL of both normal and low producers. The inhibition was dose dependent. A significant rise in the IFN-.alpha. yield was seen when PBL of "low producers" were exposed individually to either pentoxifylline or indomethacin. However, no increase in titer of IFN-.alpha. was seen when PBL of "normal producers" were exposed to either of these two agents during interferon production periods. With regard to PBL of "low producers", the enhancement of IFN-.alpha. yield was further potentiated when both indomethacin and pentoxifylline were utilized concurrently at their optimal concentrations. These results sugest that enhancement of IFN-.alpha. production by PBL of apparently healthy adults who are low producers may be possible and may have preventive value.

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