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Regulation of induced thionein gene expression in cultured mammalian cells effects of protein synthesis inhibition on translatable thionein messenger rna levels in regulatory variants of the cho cell


, : Regulation of induced thionein gene expression in cultured mammalian cells effects of protein synthesis inhibition on translatable thionein messenger rna levels in regulatory variants of the cho cell. Biochemical & Biophysical Research Communications 93(2): 343-348

The effects of the protein synthesis inhibitors cycloheximide and puromycin on functional thionein mRNA levels were examined to further delineate the regulation of thionein gene expression in Cd2+-resistant CHO [chinese hamster ovary] cell sublines proficient in Cd2+- or Zn2+-stimulated synthesis of metallothioneins. Inhibition of protein synthesis at or shortly before the time of metal-mediated induction only slightly reduces the usual increase in thionein mRNA. Protein synthesis inhibition alone does not significantly increase thionein mRNA levels. Addition of cycloheximide 4 h after Zn2+ induction increases thionein mRNA activity measured 8 h after induction by at least 40%, suggesting that protein synthesis is required for normal turnover of thionein mRNA.

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