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Regulation of insulin messenger rna abundance and adenylation dependence on hormones and matrix substrata

, : Regulation of insulin messenger rna abundance and adenylation dependence on hormones and matrix substrata. Molecular & Cellular Biology 6(1): 337-341

The insulin mRNA levels of rat insulinoma cell lines increased six- to eightfold, and the cells entered a transient state of growth arrest when they were cultured in serum-free, hormonally defined medium and on an extract of extracellular matrix derived from a basement membrane-screening tumor line, EHS. Insulinoma cultures in growth arrest responded to glucose with a two- to threefold increase in insulin secretion associated with an insulin mRNA that contained a poly(A) tail that was 120 to 140 bases longer than normal.

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