EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
EurekaMag PDF Full Text Supply ServicePDF Full Text Supply Service
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn
Follow on LinkedInFollow on Tumblr

+ Translate

Regulation of insulin receptor kinase activity by insulin mimickers and an insulin antagonist


, : Regulation of insulin receptor kinase activity by insulin mimickers and an insulin antagonist. Biochemical & Biophysical Research Communications 115(1): 245-252

Three agents which mimic insulin action in intact cells (concanavalin A, wheat germ agglutinin and polyclonal insulin receptor antibody), mimicked insulin's ability to stimulate the kinase activity of purified insulin receptors. In contrast, monoclonal insulin receptor antibody, an antagonist of insulin action, did not stimulate the phosphorylation of the insulin receptor either in intact [human lymphocytes] IM-9 cells or in purified receptor preparations. This antibody, however, antagonized the ability of insulin to stimulate the phosphorylation of the receptor both in intact cells and in the purified receptor. These studies with insulin mimickers and an insulin antagonist are consistent with a role for the kinase activity of the receptor mediating the actions of insulin.

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006288767

PMID: 6351861

DOI: 10.1016/0006-291x(83)90996-8

PDF Full Text: Regulation of insulin receptor kinase activity by insulin mimickers and an insulin antagonist


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

SURE, B., 2011: The nature of protein enrichment of refined wheat flour with cultured yeast. Federation Proceedings 6(1): 422-422

Kirk, I. W., 1998: Spray quality from CP straight stream nozzles. Nozzle manufacturers have responded to the need to control spray quality by producing straight stream nozzles for aerial applications. CP straight stream nozzles provide several adjustments to control spray quality. A study was conducted with this...

Stott, A. W., 1989: Economic performance of dairy cows as a culling criterion in response to milk quotas. A function is described to evaluate the economic performance of individual cows as a margin over feed costs, mastitis costs and insemination costs. The economic performance of 149 Jersey cows and 273 Holstein cows was estimated with this function...

Blain, Stephane; Guieu, Cecile; Claustre, Herve; Leblanc, Karine; Moutin, Thierry; Queguiner, Bernard; Ras, Josephine; Sarthou, Giraldine, 2004: Availability of iron and major nutrients for phytoplankton in the northeast Atlantic Ocean. Because of recent findings that Fe is a limiting factor for phytoplankton activity even at relatively high dissolved iron (DFe) concentrations, the potential importance of Fe limitation was revisited in the northeast Atlantic Ocean (39-45degreeN,...

Zabolotnyĭ, D.K., 1969: The endemic nature of plague, causes of its spread and the control of plague epidemics. Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii 46(7): 144-147

Dorado Martinez, C.; Rodriguez Mata, V.; Rugerio Vargas, C.; Rodriguez Martinez, E.; Pereyra Munoz, N.; Gonzalez Rivas, S.; Borgonio Perez, G.; Rivas Arancibia, S., 2002: Neural response to oxidative stress caused by repeated ozone exposure in rats is it recovery?. Repeated ozone exposure to low doses is a non-invasive model to produce an oxidative stress state. This model causes progressive brain degeneration. The aim of this work was to study biochemical and morphological brain responses found 1 and 2 week...

Williams, I. C., 1961: A list of parasitic worms, including twenty-five new records, from British birds. Tables of data are given for 68 spp. of helminth parasites, recorded from 122 wild birds of 36 different spp. in Wales. They included 22 spp. of Digenea, 33 of Cestoda, 9 of Nematoda, and 4 of Acanthocephala, with 9 spp. of helminths new to Englan...

Houston, M.; Estevez, A.; Chumley, P.; Aslan, M.; Marklund, S.; Parks, D.A.; Freeman, B.A., 1999: Binding of xanthine oxidase to vascular endothelium. Kinetic characterization and oxidative impairment of nitric oxide-dependent signaling. Concentrations of up to 1.5 milliunits/ml xanthine oxidase (XO) (1.1 micrograms/ml) are found circulating in plasma during diverse inflammatory events. The saturable, high affinity binding of extracellular XO to vascular endothelium and the effect...

Insall, J. N., 1995: Knee position indicator. Official Gazette of the United States Patent & Trademark Office Patents 1177(4): 2361, Aug 22

Antunes, L.M.; Darin, J.D.; Bianchi, N.de.L., 2001: Effects of the antioxidants curcumin or selenium on cisplatin-induced nephrotoxicity and lipid peroxidation in rats. A large number of natural products and dietary components have been evaluated as potential chemoprotective agents. In the present investigation we report the effects of pre-treatment with two dietary antioxidants, curcumin (8 mg kg-1 body wt.) or...