+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of insulin receptors in cultured human fibroblasts

, : Regulation of insulin receptors in cultured human fibroblasts. Endocrinology 109(5): 1754-1759

The ability of insulin to regulate its own receptor was investigated in cultured human fibroblasts. Physiological insulin concentrations led to a loss of insulin receptors, and this process was dependent on cellular energy and ongoing protein synthesis. The insulin concentration primarily affected the rate of receptor loss rather than the eventual cellular receptor concentration. Studies of receptor regeneration revealed that the absolute rate of insertion of new or recycled receptors into the plasma membrane was constant and independent of the amount of proceeding receptor loss or the time over which receptor loss occurred. These results are compatible with the concept that insulin-induced receptor loss in cultured human fibroblasts is a self-limited process mediated by an endocytotic internalization pathway which is dependent on new protein synthesis. Receptor regeneration is a distinct cellular process dependent on ongoing protein synthesis and does not imply represent the absence of ongoing receptor loss.

(PDF same-day service: $19.90)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006288773

PMID: 7297502

DOI: 10.1210/endo-109-5-1754

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Clarke John E. Hughes; Mayer Larry A.; Wells David E.; Costello Gerard, 1992: Ocean mapping; a Canadian perspective. U S

Altman, R.; Scazziota, A.; Rouvier, J.; Cacchione, R., 1986: Synergistic actions of paf acether and sodium arachidonate in human platelet aggregation 1. studies in normal human platelet rich plasma. The effect of sodium arachidonate and paf-acether in the activation of human platelet was studied. Concentrations of paf-acether which induced a reversible aggregation in normal human platelet rich plasma (0.029-0.0029 .mu.M) and subthreshold conc...

Dean T. Mason; James F. Spann Jr.; Robert Zelis, 1970: Quantification of the contractile state of the intact human heart maximal velocity of contractile element shortening determined by the instantaneous relation between the rate of pressure rise and pressure in the left ventricle during isovolumic systole. The American Journal of Cardiology 26(3): 0-257

Service, M. W., 1989: Rice, a challenge to health. Some of the health hazards, in particular malaria (irrigation often provides ideal breeding sites for mosquito vectors of diseases), that are often associated with rice cultivation, and the environmental measures that are employed to combat these...

Peixoto, Silvio; Cavalli, Ronaldo Olivera; Wasielesky, Wilson, 2005: Recent developments on broodstock maturation and reproduction of Farfantepenaeus paulensis. This paper describes the latest developments on maturation and reproduction of Farfantepenaeus paulensis in captivity, with special reference to the studies conducted during the last decade at the Laboratory of Mariculture, University of Rio Grand...

Doerge, D. R.; Divi, R. L., 1995: Porphyrin pi-cation and protein radicals in peroxidase catalysis and inhibition by anti-thyroid chemicals. 1. Thyroid peroxidase (TPO) catalyses the iodination and phenolic coupling reactions in the biosynthesis of thyroid hormones. 2. The two-electron oxidation of TPO by H-2O-2 produces an oxoferryl porphyrin pi-cation radical compound I that isomeriz...

Farago, Sandor., 1993: The investigation of the goose stock at the Hungarian part of Lake Ferto: a ten year study (1983-1993). Allattani Kozlemenyek, 79: 37-47

Wang, J.; Johnson, C. S.; Eisenback, J. D., 1997: Enhanced hatching of Globodera tabacum solanacearum juveniles by root exudates of flue-cured tobacco. Stimulation of hatching of a tobacco cyst nematode (Globodera tabacum solanacearum) by root exudates from resistant NC 567 and susceptible K 326 cultivars of flue-cured tobacco, Nicotiana tabacum, was investigated. Root exudates were collected by...

Owen, James D.; Strieter, Robert; Burdick, Marie; Haghnegahdar, Hamid H.; Nanney, Lilian; Shattuck Brandt, Rebecca; Richmond, Ann, 1997: Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine beta and gamma proteins. Three human MGSA/GRO genes encode 3 highly related chemokines, MGSA/GRO-alpha, -beta and -gamma. All 3 MGSA/GRO proteins bind to the same receptors, but with differing affinities, and stimulate a number of biological responses including chemotaxis...

Crumeyrolle, M.; Tournaire, M.C.; Cane, A.; Medvedev, A., 2002: The effect of some oxidized indoles on the activity of rat brain mitochondrial monoamine oxidases. There is increasing evidence, that oxidized indoles, isatin, 5-hydroxyoxindole, 2-oxindole, play important regulatory functions in the brain Isatin and 5-hydroxyoxindole share some common regulatory properties in cell cultures (Cane et al., 2000,...