EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of insulin release by ionic and electrical events in B cells


Hormone Research 27(3): 168-178
Regulation of insulin release by ionic and electrical events in B cells
This review article is an attempt to schematize the major alteractions in ionic fluxes and B cell membrane potenial that underlie the changes in insulin release brought about by glucose and by other stimulators or inhibitors. Glucose metabolism in B cells leads to closure of K channels in the plasma membrane. The resulting decrease in K+ permeability causes depolarization with activation of voltage-dependent Ca channels. An increase in Ca2+ influx ensues, which raises the cytoplasmic concentration of free Ca2+ and ultimately triggers insulin release. Tolbutamide induces a similar sequence of events by a direct action on K channels. In contrast, diazoxide antagonizes the effects of glucose by increasing K+ permeability of the B cell membrane. Among amino acids, leucine largely mimics the effects of glucose, whereas arginine depolarizes the B cell membrane because of its transport in a positively charged form.


Accession: 006288777

PMID: 2447002

DOI: 10.1159/000180806



Related references

Reciprocal links between metabolic and ionic events in islet cells. Their relevance to the rhythmics of insulin release. Diabetes & Metabolism 24(1): 11-14, 1998

Inosine partially mimics the effects of glucose on ionic fluxes, electrical activity, and insulin release in mouse pancreatic B-cells. Pflugers Archiv 410(4-5): 457-463, 1987

Inosine partially mimics the effects of glucose on ionic fluxes electrical activity and insulin release in mouse pancreatic beta cells. Pfluegers Archiv European Journal of Physiology 410(4-5): 457-463, 1987

Ionic and molecular events underlying insulin release. Journal of Physiology (Cambridge) 493P(0): 147S-148S, 1996

Impaired insulin release in aging rats: metabolic and ionic events. Experientia 49(10): 850-853, 1993

Impaired insulin release in aging rats: Metabolic and ionic events. Experientia (Basel) 49(10): 850-853, 1993

Stimulus-secretion coupling of glucose-induced insulin release. Timing of early metabolic, ionic, and secretory events. Metabolism: Clinical and Experimental 30(5): 527-532, 1981

Vasoactive intestinal polypeptide-augmented insulin release: actions on ionic fluxes and electrical activity of mouse islets. Diabetologia 36(10): 920-925, 1993

Vasoactive intestinal polypeptide-augmented insulin release: Actions to ionic fluxes and electrical activity of mouse islets. Diabetologia 36(10): 920-925, 1993

Effects of a calcium channel agonist on the electrical, ionic and secretory events in mouse pancreatic B-cells. Biochemical and Biophysical Research Communications 131(2): 980-986, 1985