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Regulation of insulin secretion by glucose during aging


Journal of Gerontology 41(1): 30-35
Regulation of insulin secretion by glucose during aging
The purpose of this study was to investigate the sensitivity of insulin secretion to glucose and its possible relationship to changes in islet glucose utilization during aging. Pancreatic islets of Langerhans were isolated from male Sprague-Dawley rats aged 2- to 24-months and perifused in vitro with glucose. Insulin concentration was determined by radioimmunoasassy. Glucose utilization was assessed by measuring the rate of conversion of 3H-5-D-glucose to 3H-H2O. The sensitivity of isolated, perifused islets to glucose was reduced during aging. Less glucose metabolism, however, may be required to elicit comparable release of insulin by islets from old than from young rats.


Accession: 006288782

PMID: 3510244

DOI: 10.1093/geronj/41.1.30



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