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Regulation of interferon gene expression mechanism of action of the if 1 locus

, : Regulation of interferon gene expression mechanism of action of the if 1 locus. Journal of Virology 62(4): 1125-1131

We have examined the mechanism of action of the If-1 interferon (IFN) regulatory locus. This locus controls the levels of circulating IFN produced in inbred mice in response to intravenous injection of Newcastle diseae virus. Mice carrying the If-1h (high) allele show circulating IFN levels 10-to 15-fold higher than those carrying the If-11 (low) allele.

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