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Regulation of interferon impaired initiation factor activity in vitro by cyclic amp and double stranded rna


, : Regulation of interferon impaired initiation factor activity in vitro by cyclic amp and double stranded rna. Proceedings of the Society for Experimental Biology and Medicine 159(3): 453-457

Interferon treatment of mouse [fibroblast] L cells causes the reduction of activity of initiation factor (eIF-2) which forms a ternary complex with Met-tRNAf and GTP. The activity of eIF from the cells treated with interferon was specifically increased when incubated with 12 .mu.M c[cyclic]AMP, but no effect of cAMP on the eIF-2 activity from untreated cells was observed. ATP (1 mM) also slightly increased the interferon-impaired eIF-2 activity. The restoration of activity of eIF-2 from interferon-treated cells was completely prevented by the addition of inhibitors of protein kinases [aminopurine (2 mM) or a relatively high concentration (5 .mu.g/ml) of ds(double stranded)RNA (poly rI:poly rC)] without a direct effect on normal eIF-2 activity. Low concentrations of dsRNA (50 ng/ml), which activate certain protein kinases, strongly stimulated the reduction of eIF activity induced by interferon. Different protein kinases may be involved in the interferon-induced reduction of eIF-2 activity and the restoration of interferon-impaired eIF-2 activity.

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