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Regulation of interleukin 2 receptor expression interleukin 2 as an inducing signal for the expression of its own receptor on a murine t helper cell line


European Journal of Immunology 15(7): 723-727
Regulation of interleukin 2 receptor expression interleukin 2 as an inducing signal for the expression of its own receptor on a murine t helper cell line
The interleukin 2 receptor (IL 2R) expression of a terpolymer of GAT-specific T helper (Th) cell line, L14, was studied using 2 different rat monoclonal antibodies specific for the murine IL 2R, 7D4 and 5A2-2. L14 T cells expressed IL 2R transiently, but contrary to the general assumption that IL 2R expression is maintained only by periodic antigen stimulation, it was observed that IL 2 itself was able to regulate the level of IL 2R on L14 Th lymphocytes. In particular, it was found that L14 T cells, which had not been recently stimulated and which expressed a very low level of high affinity IL 2R, could be induced to exhibit a high level of this receptor after exposure to recombinant IL 2, in the absence of any specific signal. The Th cell line 52.3 used as control could be induced to express high levels of IL 2R only after exposure to GAT; nevertheless, IL 2 seems to play a critical role in the in vitro survival of the resting state of 52.3 T cells.


Accession: 006288806



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