+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of intracellular concentration of low molecular weight substances in bacteria

Izvestiya Akademii Nauk SSSR Seriya Biologicheskaya (5): 715-721
Regulation of intracellular concentration of low molecular weight substances in bacteria
It is shown that active transport of low-molecular substances from bacteria cells by the systems, localized in cytoplasmic membrane, is an effective mechanism of such substances intracellular pool's regulation. For example, the active efflux apparatus of tetracyclines from the cells of E. coli strains, containing plasmid R621a, is firmly connected with cell membrane and conserved in membraneous vesicles. The direct correlation between the regulation of tetracycline intracellular level and glutamic acid pool, that indicates the common transport pathways for these substances from bacterial cell, is determined. The pool of aromatic amino acids is regulated in the same way in extreme halophytes (fam. Halobacteriaceae), related to arachebacteria. The presence of these mechanisms of regulation in microorganisms, differed in physiology and ecology, demonstrates their significant value in the intracellular level control of substances, participating as inhibitors or activators of metabolism. In connection with this it is possible to discuss the new level of metabolic regulation, which is suggested to determine as membraneous regulation.

Accession: 006288854

Related references

Regulation of the intracellular concentration of low-molecular substances in bacteria. Izvestiia Akademii Nauk Sssr. Seriia Biologicheskaia: 715-721, 1985

Contribution to the theory of the viscosity of solutions of high molecular weight substances III A general consideration of the dependence of the vis-cosity of solutions of high molecular weight substances on the concentration. 1945

Mechanical properties of substances of high molecular weight; rigidities of gelatin gels; dependence on concentration, temperature and molecular weight. Journal of the American Chemical Society 70(6): 2244-2249, 1948

Efficient intracellular delivery of proteins and low molecular weight substances via polyoma virus-like particles. Journal of Peptide Science 8(Supplement): S215, 2002

Possible causes of an increase in the concentration of medium molecular weight substances in pathological conditions. Patologicheskaya Fiziologiya i Eksperimental'naya Terapiya (4): 13-14, 1991

A new method for the concentration of high and low molecular weight substances and for their recovery following gel electrophoresis, partition and precipitation experiments. Biochimica et Biophysica Acta 237(3): 395-403, 1971

Concentration of plasma middle molecular weight substances and clinical condition of patients undergoing short-time regular dialysis treatment. Artificial Organs 4 Suppl: 173-176, 1981

Ratio of intracellular precursors concentration and their flux influences hyaluronic acid molecular weight in Streptococcus zooepidemicus and recombinant Lactococcus lactis. Bioresource Technology 163: 222-227, 2015

Biosynthesis of the insulin receptor in rat adipose cells intracellular processing of the molecular weight 190000 molecular weight proreceptor. Biochemical Journal 232(1): 71-78, 1985

Clinical significance of middle molecular weight and low molecular weight substances in blood serum. Vrachebnoe Delo (6): 10-16, 1991