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Regulation of intracellular concentration of low molecular weight substances in bacteria

, : Regulation of intracellular concentration of low molecular weight substances in bacteria. Izvestiya Akademii Nauk SSSR Seriya Biologicheskaya (5): 715-721

It is shown that active transport of low-molecular substances from bacteria cells by the systems, localized in cytoplasmic membrane, is an effective mechanism of such substances intracellular pool's regulation. For example, the active efflux apparatus of tetracyclines from the cells of E. coli strains, containing plasmid R621a, is firmly connected with cell membrane and conserved in membraneous vesicles. The direct correlation between the regulation of tetracycline intracellular level and glutamic acid pool, that indicates the common transport pathways for these substances from bacterial cell, is determined. The pool of aromatic amino acids is regulated in the same way in extreme halophytes (fam. Halobacteriaceae), related to arachebacteria. The presence of these mechanisms of regulation in microorganisms, differed in physiology and ecology, demonstrates their significant value in the intracellular level control of substances, participating as inhibitors or activators of metabolism. In connection with this it is possible to discuss the new level of metabolic regulation, which is suggested to determine as membraneous regulation.

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Plakunov, V.K.; Volkova, I.M.; Lebedeva, Z.D.; Lobyreva, L.B.; Matveeva, N.I., 1985: Regulation of the intracellular concentration of low-molecular substances in bacteria. Izvestiia Akademii Nauk Sssr. Seriia Biologicheskaia: 715-721

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