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Regulation of iso propyl malate isomerase ec 4.2.1.33 synthesis in neurospora crassa


Journal of Bacteriology 133(2): 794-801
Regulation of iso propyl malate isomerase ec 4.2.1.33 synthesis in neurospora crassa
The capacity to synthesize isopropylmalate isomerase (EC 4.2.1.33) by N. crassa increased during induction in the presence of cycloheximide but was inhibited by proflavine and other inhibitors of RNA synthesis. Turnover of the enzyme once formed appeared negligible, but the message (measured as enzyme-forming capacity) had a half-life of 4-8 min. A comparison of the kinetics of induction in the wild type and a newly isolated .alpha.-isopropylmalate-permeable strain suggested strongly that feedback control by leucine of .alpha.-isopropylmalate production can adequately serve as the primary physiological regulator of endogenous inducer concentration. Genetic data are presented which implicate the involvement of 2 unlinked genes, ipm-1 and imp-2, in determining permeation of .alpha.-isopropylmalate.


Accession: 006288888



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