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Regulation of l amino acid oxidase and d amino acid oxidase in neurospora crassa


, : Regulation of l amino acid oxidase and d amino acid oxidase in neurospora crassa. Molecular & General Genetics 186(1): 33-39

N. crassa possesses an inducible L-amino acid oxidase that is expressed only when cells are derepressed for N in the presence of an amino acid. Enzyme synthesis requires both induction by an amino acid and simultaneous N catabolite derepression. C limitation in the presence of an amino acid does not permit induction of L-amino acid oxidase. The nit-2 gene is a major regulatory locus which is believed to mediate N catabolite repression in Neurospora. Mutants of nit-2 are repressed for L-amino acid oxidase activity under conditions which lead to good enzyme induction in wild type and nit-2 revertants. The loss of the enzyme in nit-2 mutants does not result from inducer exclusion, which suggests that the nit-2 gene product has a direct role in controlling the expression of this enzyme. Substantial amounts of L-amino acid oxidase were detected in the growth medium as well as in cell extracts of the wild type strain. Biochemical data indicates that the intracellular and the extracellular L-amino acid oxidases are identical. Inhibitors of protein and of RNA synthesis block accumulation of L-amino acid oxidase, suggesting that enzyme expression is controlled at the level of transcription. D-amino acid oxidase can be detected in cell extracts of Neurospora grown in the presence of a D-amino acid. The enzyme is present in cys-3 mutants and is not repressed by high concentrations of sulfate or N indicating that D-amino acid oxidase is not a member of the S or N regulatory circuits of this organism.

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