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Regulation of l asparaginase formation by amino acids in bacillus mesentericus

, : Regulation of l asparaginase formation by amino acids in bacillus mesentericus. Mikrobiologiya 45(2): 259-265

The role of amino acids in regulation of L-asparaginase formation was studied in B. mesentericus 43A. Aspartic acid and, to a less extent, asparagine repress biosynthesis of the enzyme. Glutamic acid, glutamine and 15 other amino acids, added separately at a concentration of 10 or 20 mM to the growing culture, have no effect on the enzyme activity. Addition of a combination of all 18 amino acids, each at a concentration of 4 mM, to the culture represses the activity by 64%; addition of an acid hydrolysate of lactalbumin (10 g/l) represses the enzyme activity by 80%. A mixture of amino acids without aspartic acid and asparagine also displays a strong repressing action. Amino acids formed from aspartic acid.sbd.lysine, methionine and not repress enzyme biosynthesis together or separately. Ammonium N also does not regulate asparaginase formation. The cumulative repressing action of amino acids is probably manifested via catabolite repression.

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