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Regulation of l ornithine decarboxylase activity in the thymus and liver of rats by adrenal hormones


, : Regulation of l ornithine decarboxylase activity in the thymus and liver of rats by adrenal hormones. Cytobios 45(180): 25-34

The activity of L-ornithine decarboxylase (EC 4.1.1.17, ODC) has become a useful indicator of hormone responsiveness. Various regimens of dexamethasone, aldosterone and epinephrine, alone or in combination, were administered to adrenalectomized rats either in acute or chronic doses. In addition, adrenalectomized rats, which were chronically treated with aldosterone and epinephrine, were given a single injection of 50 .mu.g dexamethasone and sacrificed at various time intervals after hormone treatment. Hepatic and thymic ODC activity was measured. The expected dexamethasone effect, an increase in hepatic and a decrease in thymic ODC, was observed. This study also revealed that aldosterone induced similar responses in these tissues. Epinephrine had the opposite effect since chronic administration of dexamethasone or aldosterone with epinephrine resulted in control levels of ODC. Furthermore, when aldosterone and epinephrine were chronically administered to adrenalectomized rats, to study the acute effects of dexamethasone on rat thymus and liver, the time course of the response in each tissue was found to be distinct. The influence of the adrenal gland on rat thymus and liver is not restricted only to glucocorticoids, but may also involve other hormones which it secretes.

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Related references

Zahner, S.L.; Prahlad, K.V.; Mitchell, J.L., 1986: Regulation of ODC activity in the thymus and liver of rats by adrenal hormones. The activity of L-ornithine decarboxylase (EC 4.1.1.17, ODC) has become a useful indicator of hormone responsiveness. Various regimens of dexamethasone, aldosterone and epinephrine, alone or in combination, were administered to adrenalectomized ra...

Brosnan, M.E.; Ilic, V.; Williamson, D.H., 1982: Regulation of the activity of ornithine decarboxylase and S-adenosylmethionine decarboxylase in mammary gland and liver of lactating rats. Ornithine decarboxylase (ODC) activity in mammary tissue of rats at peak lactation nursing litters of 8-11 pups was barely detectable after starvation for 24 h and was restored following 5 h but not 2.5 h of refeeding. Prolactin deficiency induced...

Brosnan, M.E.; Ilic, V.; Williamson, D.H., 1982: Regulation of the activity of ornithine decarboxylase and S-adenosylmethionine decarboxylase in mammary gland and liver of lactating rats. Effects of starvation, prolactin and insulin deficiency. 1. Starvation caused a marked decrease in the activity of ornithine decarboxylase in mammary gland, together with a lesser decrease in the activity of S-adenosylmethionine decarboxylase and a marked fall in milk production. Liver ornithine decarbo...

Brosnan, M.E.; Ilic, V.; Williamson, D.H., 1982: Regulation of the activity of ornithine decarboxylase ec 4.1.1.17 and s adenosyl methionine decarboxylase ec 4.1.1.50 in mammary gland and liver of lactating rats effects of starvation prolactin and insulin deficiency. Starvation caused a marked decrease in the activity of ornithine decarboxylase in mammary gland, together with a lesser decrease in the activity of S-adenosylmethionine decarboxylase and a marked fall in milk production. Liver ornithine decarboxyl...

Hirvonen A.; Immonen T.; Leinonen P.; Alhonen Hongisto L.; Janne O.A.; Janne J., 1988: Effect of dexamethasone on the activity and expression of ornithine decarboxylase in rat liver and thymus. A single intraperitoneal injection of the synthetic glucocorticoid dexamethasone into rats resulted in a marked stimulation (more than 60-fold) of hepatic ornithine decarboxylase (ODC) at 4 h after the injection, whereas the enzyme activity in thy...

Byus, C.V.; Russell, D.H., 1976: Possible regulation of ornithine decarboxylase activity in the adrenal medulla of the rat by a cAMP-dependent mechanism. Biochemical Pharmacology 25(14): 1595-1600

Byus, C.V.; Russell, D.H., 1976: Possible regulation of ornithine decarboxylase activity in the adrenal medulla of the rat by a cyclic amp dependent mechanism. That ornithine decarboxylase, the rate-limiting enzyme in polyamine biosynthesis, may be controlled by a c[cyclic]AMP-dependent mechanism, was investigated in the rat adrenal medulla. Exposure of rats to cold (4.degree., 2 h) leads to increased ch...

Slozhenikina, L.V.; Fialkovskaya, L.A., 1992: The effect of single gamma-irradiation of rats on ornithine decarboxylase activity in the thymus and pulmonary tissue. In studying the dose (0.1-6 Gy) and time (2 h to 180 days) dependence of ornithine decarboxylase activity, it was found that deviations from the control were more pronounced in the thymus than in the pulmonary tissue. The radiation effect was a fu...

Reddy, P.R.; Villee, C.A., 1975: Stimulation of ornithine decarboxylase activity by gonadotropic hormones and cyclic AMP in the testis of immature rats. Biochemical and Biophysical Research Communications 65(4): 1350-1354

Knopp, J.; Brtko, J., 1990: Nuclear binding of thyroid hormones and activity of malic enzyme and ornithine decarboxylase in rat liver during postnatal development. The binding of 3,5,3'-L-triiodothyronine (T3) and thyroxine (T4) on liver nuclear receptors and the activity of malic enzyme and ornithine decarboxylase was examined in infantile rats aged in 1, 3, 7, 23, 29 days and in adult rats. No changes...