EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
EurekaMag PDF Full Text Supply ServicePDF Full Text Supply Service
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn
Follow on LinkedInFollow on Tumblr

+ Translate

Regulation of large coronary vessels by adrenergic mechanisms in conscious dogs


, : Regulation of large coronary vessels by adrenergic mechanisms in conscious dogs. Basic Research in Cardiology 76(5): 508-517

The effects of .alpha.- and .beta.-adrenergic stimulation were examined in conscious dogs on measurements of left circumflex coronary blood flow and coronary arterial diameter and on calculations of mean coronary resistance (MCR) and left circumflex coronary internal cross-sectional area (CSA). Methoxamine (50 .mu.g/kg per min), after transiently increasing left circumflex coronary dimensions, induced sustained reductions in left circumflex coronary diameter (9 .+-. 2%) and CSA (27 .+-. 5%) at a time when mean arterial pressure rose by 65 .+-. 5%, left ventricular (LV) dP/dt [change in pressure over time] had decreased only slightly, and heart rate and mean coronary blood flow were at control levels. Isoproterenol (0.1 .mu.g/kg per min) increased heart rate by 66 .+-. 8%, LV dP/dt by 58 .+-. 5%, and CSA by 17 .+-. 3%, while it decreased mean arterial pressure by 12 .+-. 1% and MCR by 44 .+-. 5%. After .beta.1-adrenergic receptor blockade and with heart rate held constant, isoproterenol did not increase LV dP/dt but decreased mean arterial pressure similarly (13 .+-. 2%) and induced attenuated increases in CSA (6 .+-. 1%), and decreases in MCR (17 .+-. 3%). After combined .beta.1- and .beta.2-adrenergic receptor blockades isoproterenol induced no significant effects. In the conscious dog, large coronary vessels not only react passively to changes in aortic pressure but also undergo substantial active changes. .alpha.-Adrenergic stimulation is sufficiently powerful to reduce CSA, despite the opposing elevation of distending pressure. Large vessels appear to be regulated by .beta.1-adrenergic mediated increase in myocardial metabolic demands and by .beta.2-adrenergic mediated vasodilation.

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006288964

PMID: 6272684

DOI: 10.1007/bf01908352

PDF Full Text: Regulation of large coronary vessels by adrenergic mechanisms in conscious dogs


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Shelley, H.; Coyne, R., 2009: Employing healthcare assistants in paediatric oncology units. This article examines the potential benefits of employing healthcare assistants in paediatric oncology departments. It explores the implications for role definition, workforce planning, training, regulation, accountability and delegation. The arti...

Nakagawa, M.; Nishijima, S.; Asada, Y., 1986: Effect of free fatty acids on Propionibacterium acnes and Staphylococcus epidermidis. Nihon Hifuka Gakkai Zasshi. Japanese Journal of Dermatology 96(10): 1007-1011

De Luca, Annamaria; Pierno, S.; Desaphy, J.F.; Liantonio, A.; Camerino, C.; Frigeri, A.; Nicchia, G. P.; Svelto, M.; Leoty, C.; Camerino, D. Conte, 2000: Effect of rat hindlimb suspension on cable properties, ionic conductances and fiber type composition of slow-twitch muscle. Biophysical Journal 78(1 Part 2): 363A, Jan

Lissi, E.; Blanc, A. C. Cardini, L. Cassoli, P., 1962: Determinazione delle faune dei Bothroi di Locri. Quaternaria, 5(198-61): 298-299

Carlomagno S.; Vecchio G.; Aloj S.M., 1971: The biosynthesis of thyro globulin study of the poly ribosomal thyroid fraction in rats. Atti della Accademia Nazionale dei Lincei Rendiconti Classe di Scienze Fisiche Matematiche e Naturali 50(2): 224-232

Keating, J.P.; Mouat, C.; Strettell, M.D., 2001: Appendiceal carcinoma masquerading as a rectal villous adenoma. Gastrointestinal Endoscopy 53(1): 124-125

Isono, Mitsuo; Abe, Tatsuya; Goda, Makoto; Ishii, Keisuke; Kobayashi, Hidenori, 2002: Middle cerebral artery dissecting aneurysm causing intracerebral hemorrhage 4 years after the non-hemorrhagic onset: A case report. BACKGROUND: We report a case of dissecting middle cerebral artery (MCA) aneurysm causing intracerebral hemorrhage 4 years after the non-hemorrhagic onset. CASE DESCRIPTION: A 30-year-old male was diagnosed with an unruptured dissecting MCA aneurys...

Houppert, A.S.; Kwiatkowski, E.; Glass, E.M.; DeBord, K.L.; Merritt, P.M.; Schneewind, O.; Marketon, M.M., 2012: Identification of chromosomal genes in Yersinia pestis that influence type III secretion and delivery of Yops into target cells. Pathogenic Yersinia species possess a type III secretion system, which is required for the delivery of effector Yop proteins into target cells during infection. Genes encoding the type III secretion machinery, its substrates, and several regulator...

Kubota, T.; Kitamura, Y.; Ogawa, H.; Suzuki, Y.; Suzuki, K.; Oka, K., 2002: Intracellular magnesium mobilization mechanism in pc12 cell. Although magnesium ion (Mg2+) is an essential element for hundreds of enzymatic reactions, the Mg2+ dynamics in cells are still unknown. In this study, we investigated the Mg2+ mobilization mechanism in PC12 cells with a Mg2+ indicator, KMG-20. De...

Comin, D., 1944: The response of some muck crops to the application of minor elements. The value of certain amendments such as CuSO4, manganese sulfate, and a proprietary material containing sulfates of Mn, Cu, Zn and Fe was tested on muck soil of pH 5.5-5.8 and in a good state of fertility. Small but consistent increases in yields...